SAB4502029
Anti-NPY2R antibody produced in rabbit
affinity isolated antibody
别名:
NPY-Y2 receptor, NPY2-R, NPY2R, Neuropeptide Y receptor type 2
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IF, WB
Citations:
8
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 42 kDa
species reactivity
human, mouse, rat
concentration
~1 mg/mL
technique(s)
ELISA: 1:1000, immunofluorescence: 1:100-1:500, western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... NPY2R(4887)
General description
The NPY2R (neuropeptide Y receptor Y2) gene is mapped to human chromosome 4q32.1 and codes for a G-protein-coupled receptor. NPY2R is predominantly expressed in central nervous system including hypothalamus, brain stem, hippocampus, lateral septum and amygdala. NPY2 receptors are also distributed in the liver, spleen, intestine, adipose tissue and muscle.
Immunogen
The antiserum was produced against synthesized peptide derived from human NPY2R.
Immunogen Range: 1-50
Immunogen Range: 1-50
Biochem/physiol Actions
NPY2R (neuropeptide Y receptor Y2) acts as a presynaptic autoreceptor and heteroreceptor. It regulates the release of both endogenous NPY and neurotransmitters such as glutamate and γ–aminobutyric acid (GABA). NPY exerts its anxiolytic function via the NPY2R. Deletion of NPY2R results in retardation of the anticonvulsant actions of NPY. NPY2R plays an important role in the process of bone formation.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
此项目有
Debanjan Chakroborty et al.
British journal of cancer, 127(8), 1440-1449 (2022-07-29)
Resistance to anti-angiogenic therapies targeting vascular endothelial growth factor-A (VEGF-A) stems from VEGF-A independent angiogenesis mediated by other proangiogenic factors. Therefore identifying these factors in colon adenocarcinoma (CA) will reveal new therapeutic targets. Neuropeptide Y (NPY) and Y2 receptor (Y2R)
Unwinding of the C-Terminal Residues of Neuropeptide Y is critical for Y2 Receptor Binding and Activation.
Kaiser A
Angewandte Chemie (International Edition in English), 54(25), 7446-7449 (2015)
Tao Yang et al.
Cellular & molecular biology letters, 28(1), 60-60 (2023-07-28)
Sebaceous glands (SGs) synthesize and secret sebum to protect and moisturize the dermal system via the complicated endocrine modulation. Dysfunction of SG are usually implicated in a number of dermal and inflammatory diseases. However, the molecular mechanism behind the differentiation
Mayur J Patil et al.
PloS one, 13(6), e0198601-e0198601 (2018-06-05)
Peptidergic sensory neurons play a critical role in nociceptive pathways. To precisely define the function and plasticity of sensory neurons in detail, new tools such as transgenic mouse models are needed. We employed electrophysiology and immunohistochemistry to characterize in detail
Viswanthram Palanivel et al.
Cells, 11(22) (2022-11-27)
Neuropeptide Y (NPY), a sympathetic neurotransmitter, is involved in various physiological functions, and its dysregulation is implicated in several neurodegenerative diseases. Glutamate excitotoxicity, endoplasmic reticulum (ER) stress, and oxidative stress are the common mechanisms associated with numerous neurodegenerative illnesses. The
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