SAB4502101
Anti-TNNI3K antibody produced in rabbit
affinity isolated antibody
别名:
Cardiac ankyrin repeat kinase TNNI3K, Serine/threonine-protein kinase TNNI3K TNNI3-interacting kinase
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IHC
Citations:
2
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 104 kDa
species reactivity
rat, mouse, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000, immunohistochemistry: 1:50-1:100
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... TNNI3K(51086)
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General description
Anti-TNNI3K antibody detects endogenous levels of total TNNI3K protein.
The TNNI3K (TNNI3 interacting kinase) gene is a novel cardiac troponin I-interacting kinase gene and is mapped to human chromosome 1p31.1. The gene is expressed in cardiomyocytes. The encoded protein belongs to mitogen-activated protein kinase kinase kinase (MAPKKK) family. Tnni3k consists of seven to ten ankyrin repeats at the N terminal, a Ser/Thr and Tyr kinase domain, and a Ser-rich domain at the C-terminal.
Immunogen
The antiserum was produced against synthesized peptide derived from human TNNI3K.
Immunogen Range: 301-350
Immunogen Range: 301-350
Biochem/physiol Actions
Overexpression of TNNI3K (TNNI3 interacting kinase) may induce and increase cardiac myogenesis and performance respectively. It also might inhibit ventricular remodeling, caused by ischemia. TNNI3K might be associated with the development of cardiac hypertrophy. TNNI3K is known to be associated with atrioventricular conduction disease, acute coronary syndrome and obesity.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Overexpression of Cardiac-Specific Kinase TNNI3K Promotes Mouse Embryonic Stem Cells Differentiation into Cardiomyocytes.
Wang Y
Cellular Physiology and Biochemistry, 41(1), 381-398 (2017)
TNNI3K could be a novel molecular target for the treatment of cardiac diseases.
Lai ZF
Recent Patents on Cardiovascular Drug Discovery, 4(3), 203-210 (2009)
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