SMB00445
灵芝酸 A
≥98% (HPLC)
别名:
(2R,6R)-6-[(5R,7S,10S,13R,14R,15S,17R)-7,15-二羟基-4,4,10,13,14-五甲基-3,11-二氧-2,5,6,7,12,15,16,17-八氢-1H-环戊基a[a]菲烯-17-基]-2-甲基-4-氧庚酸, (7β,15α,25R);7,15-二羟基-3,11,23-三氧-8-烯-26-酸
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关于此项目
经验公式（希尔记法）:
C30H44O7
化学文摘社编号:
分子量:
516.67
UNSPSC Code:
12352205
PubChem Substance ID:
NACRES:
NA.25
SMILES string
OC(C(C)CC(C[C@@H](C)[C@H]1C[C@H](O)[C@@]([C@]1(C)CC2=O)(C)C3=C2[C@]4(C)C(C[C@@H]3O)C(C)(C)C(CC4)=O)=O)=O
InChI
1S/C30H44O7/c1-15(10-17(31)11-16(2)26(36)37)18-12-23(35)30(7)25-19(32)13-21-27(3,4)22(34)8-9-28(21,5)24(25)20(33)14-29(18,30)6/h15-16,18-19,21,23,32,35H,8-14H2,1-7H3,(H,36,37)/t15-,16?,18-,19+,21?,23+,28+,29-,30+/m1/s1
InChI key
DYOKDAQBNHPJFD-ZQEHRSJRSA-N
assay
≥98% (HPLC)
form
powder
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
−20°C
Quality Level
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General description
灵芝酸A(Ganoderic Acid A)或GAA是灵芝(Ganoderma lucidum)真菌中最丰富的三萜类物质之一。GAA的化学结构中有四个环，在支链上有一个双键和一个末端羧基。
Application
灵芝酸A已用于：
- 研究其对缺氧诱导大鼠心肌细胞(H9c2)损伤的保护作用
- 作为参考标准品，研究其对豇豆植物中花生芽坏死病毒(GBNV)的抑制和抗病毒作用
- 作为傅里叶变换红外(FT-IR)光谱技术的标准品，分析灵芝来源的次级代谢物
Biochem/physiol Actions
灵芝酸A(GAA)可改善高脂饲料(HFD)喂养小鼠的脂质代谢、肠道菌群组成和高脂血症。它在多项体外研究中被证明可作为抗癌药物，抑制乳腺癌、人肝细胞癌细胞和骨肉瘤的细胞增殖。灵芝酸A对脑卒中后抑郁(PSD)大鼠模型具有抗抑郁样行为、炎症和神经损伤的神经保护作用。还具有抗人免疫缺陷型病毒(HIV-1)活性。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Xiaohong Zhang et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 50(6), 2086-2096 (2018-11-12)
Ganoderic acid A (GAA) isolated from Ganoderma lucidum, shows various benefit activities, such as anti-tumor activity, anti-HIV activity and hepatoprotective activity. However, the potential effects of GAA on hypoxia-induced injury of cardiomyocytes are still unclear. In this study, we aimed
Bingji Ma et al.
North American journal of medical sciences, 3(11), 495-498 (2012-03-01)
Recently a series of triterpenoids were isolated from ganoderma spores and have drawn the attention of chemists and pharmacists. The aim of this review is to summarize the triterpenoids and their bioactivities of ganoderma spores. The chemical and biological literatures
FT-IR Spectroscopic Characteristics of Ganoderma lucidum Secondary Metabolites
Sangeetha B, et al.
Current Journal of Applied Science and Technology null
Hong Li et al.
Phytotherapy research : PTR, 34(3), 640-648 (2019-11-20)
Ganoderic Acid A (GAA) is often applied for healing cardiovascular and cerebrovascular ailments, but the influences in cerebral ischemia injury are still hazy. The research delved into the functions of GAA in hypoxia-triggered impairment in PC12 cells. PC12 cells received
Xu Wang et al.
Molecular medicine reports, 16(4), 3894-3900 (2017-07-22)
Ganoderic acid A (GA‑A), a triterpenoid, has been demonstrated to suppress cell proliferation in various cancers, including breast cancer and osteosarcoma. However, its effect on human hepatocellular carcinoma (HCC) remains to be elucidated. The present study aimed to investigate the
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