SML0041
巴马司他
≥98% (HPLC), powder, matrix metalloproteinase inhibitor
别名:
BB-94；（2R,3S）-N4- 羟基-N1-[（1S）-2-（甲基氨基）-2-氧代-1-（苯甲基）乙基] -2-（2-甲基丙基）-3-[（2-噻吩基硫基基）甲基] 丁二酰胺
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关于此项目
经验公式（希尔记法）:
C23H31N3O4S2
化学文摘社编号:
分子量:
477.64
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
巴马司他, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to tan
solubility
DMSO: ≥15 mg/mL
shipped in
wet ice
storage temp.
−20°C
SMILES string
CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)[C@H](CSc2cccs2)C(=O)NO
InChI
1S/C23H31N3O4S2/c1-15(2)12-17(18(22(28)26-30)14-32-20-10-7-11-31-20)21(27)25-19(23(29)24-3)13-16-8-5-4-6-9-16/h4-11,15,17-19,30H,12-14H2,1-3H3,(H,24,29)(H,25,27)(H,26,28)/t17-,18+,19+/m1/s1
InChI key
XFILPEOLDIKJHX-QYZOEREBSA-N
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Application
巴马司他已在多种研究中被用于抑制基质金属蛋白酶（MMP）的活性。
Biochem/physiol Actions
巴马司他是一种有效的广谱基质金属蛋白酶（MMP）抑制剂。
巴马司他是基质金属蛋白酶（MMP）的异羟肟酸类抑制剂。它抑制小鼠模型中肺肿瘤的生长和扩散，乳腺癌再生和人结肠肿瘤的生长和扩散。巴马司他降低 MMP 介导的血管功能障碍和血管壁损伤，并增强牙科粘合剂的密封性能和粘合强度。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Ursula Mirastschijski et al.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 18(2), 223-234 (2010-04-23)
The ability to regulate wound contraction is critical for wound healing as well as for pathological contractures. Matrix metalloproteinases (MMPs) have been demonstrated to be obligatory for normal wound healing. This study examined the effect that the broad-spectrum MMP inhibitor
S100A4 elevation empowers expression of metastasis effector molecules in human breast cancer
Ismail TM, et al.
Cancer Research, 77(3), 780-789 (2017)
Crotalus atrox disintegrin reduces hemorrhagic transformation by attenuating matrix metalloproteinase-9 activity after middle cerebral artery occlusion in hyperglycemic male rats
McBride DW, et al.
Journal of Neuroscience Research (2018)
A Almahdy et al.
Journal of dental research, 91(6), 605-611 (2012-04-21)
Matrix metalloproteinase (MMP) inhibition has been shown to reduce adhesive bond degradation when applied as a pre-conditioner, adding to clinical steps in the placement of adhesives, but their incorporation within dental adhesives has not been fully explored. This study examined
M M Bildt et al.
Journal of periodontal research, 44(2), 266-274 (2008-11-01)
Orthodontic tooth movement requires remodeling of the periodontal tissues. The matrix metalloproteinases (MMPs) degrade the extracellular matrix components of the periodontal ligament, while the tissue inhibitors of metalloproteinases (TIMPs) control their activity. Synthetic MMP inhibitors have been developed to inhibit
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML0041-25MG | 04061833221617 |
| SML0041-5MG | 04061837076640 |
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