T7383
丁卡因
≥98% (TLC)
别名:
4-(丁氨基)-苯甲酸-2-(二甲氨基)乙酯
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关于此项目
经验公式（希尔记法）:
C15H24N2O2
化学文摘社编号:
分子量:
264.36
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
202-316-6
MDL number:
biological source
synthetic (organic)
Quality Level
assay
≥98% (TLC)
form
powder
technique(s)
toxicology assay: suitable
storage temp.
2-8°C
SMILES string
CCCCNc1ccc(cc1)C(=O)OCCN(C)C
InChI
1S/C15H24N2O2/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3/h6-9,16H,4-5,10-12H2,1-3H3
InChI key
GKCBAIGFKIBETG-UHFFFAOYSA-N
Gene Information
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General description
Tetracaine belongs to the amino-ester class and has a pKa of 8.46.
Application
Tetracaine has been used as an anesthetic and to lower the glucose synthesis in upper small intestinal infusions. It has also been used to inhibit ryanodine receptors (RyRs) in rats.
眼用局部麻醉药；用于脊髓麻醉
Tetracaine can be used as a research tool for studying E-C coupling in both skeletal as well as cardiac muscle. The product is a local anaesthetic drug used for studying the impact of numerous drugs on Tumour-necrosis-factor (TNF)-mediated cytotoxicity as well as TNF-induced arachidonic acid release.
Biochem/physiol Actions
Tetracaine blocks intracellular sodium channels. It mediates phosphorylation of eukaryotic initiation factor 2 (eIF2 α) via translational inhibition of P-body formation.
阻断 Ca2+ 从肌浆网的电压敏感性释放。
Tetracaine also refers as 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester interfere with calcium movement in muscle and non-muscle cells and can inhibit potassium-induced as well as caffeine-induced shortening of outer hair cells (OHC′s). But, the product can′t inhibit electrically-induced shortening of OHC′s.The product can also stimulate caspase activation and inhibits pro-survival signalling pathways which in turn induce human renal cell apoptosis.
Preparation Note
250 mg of tetracaine dissolves in 5 ml of EtOH to yield a clear, colorless solution. The product is also soluble in chloroform and ether at a ratio of 1:2 and in ethanol at 1:5. It is very slightly soluble in water.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Carc. 2 - Skin Sens. 1
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
法规信息
新产品
此项目有
Pharmacological considerations for Regional Anesthesia
Principles and Practice of Opthalmic Anesthesia (2018)
Insect morphogenetic hormones and developmental mechanisms in the nematode, Nematospiroides dubius.
R D Dennis
Comparative biochemistry and physiology. A, Comparative physiology, 53(1), 53-56 (1976-01-01)
Tetracaine, a local anesthetic, preferentially induces translational inhibition with processing body formation rather than phosphorylation of eIF2alpha in yeast
Araki T, et al.
Current Genetics, 61(1), 43-53 (2015)
N Slepecky et al.
Hearing research, 32(1), 11-21 (1988-01-01)
Outer hair cell (OHC) shortening has previously been induced in vitro by the application of solutions containing high potassium (a depolarizing agent), acetylcholine (a suggested efferent transmitter) and cationized ferritin (a positively charged macromolecule), as well as by electrical current.
Lactobacillus gasseri in the upper small intestine impacts an ACSL3-dependent fatty acid-sensing pathway regulating whole-body glucose homeostasis
Bauer PV, et al.
Cell Metabolism, 27(3), 572-587 (2018)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| T7383-100G | 04061833027479 |
| T7383-25G | 04061837372759 |
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