T7883

甲氧苄啶

Name: 甲氧苄啶
Brand: SIGMA

≥98.5%

别名:

2,4-二氨基-5-(3,4,5-三甲氧基苄基)嘧啶, NSC 106568

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经验公式（希尔记法）:

C₁₄H₁₈N₄O₃

化学文摘社编号:

738-70-5

分子量:

290.32

UNSPSC Code:

51285203

NACRES:

NA.85

PubChem Substance ID:

24278201

EC Number:

212-006-2

Beilstein/REAXYS Number:

625127

MDL number:

MFCD00036761

主要文件

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Quality Level

200

assay

≥98.5%

form

powder

storage condition

(Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)

color

white to light yellow

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, mycobacteria

mode of action

DNA synthesis | interferes, enzyme | inhibits

storage temp.

2-8°C

SMILES string

COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC

InChI

1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)

InChI key

IEDVJHCEMCRBQM-UHFFFAOYSA-N

Gene Information

human ... DHFRP1(573971), KCNH1(3756)
rat ... Dhfr(24312)

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General description

化学结构：嘧啶

Application

主要作为抗细菌剂。二氢叶酸还原酶抑制活性和原核酶选择性。

甲氧苄啶是最主要的抗细菌剂。它有二氢叶酸还原酶抑制活性和原核酶选择性。它被用来治疗尿道感染，轻度急性前列腺炎，复发性膀胱炎，怀孕期间无症状菌尿和呼吸道感染。

Biochem/physiol Actions

甲氧苄啶和磺胺甲恶唑结合，通过阻碍核苷酸合成，干扰细菌细胞叶酸细胞代谢。甲氧苄啶和二氢叶酸还原酶结合，抑制二氢叶酸（DHF）和四氢叶酸（THF）还原。THF是胸腺嘧啶合成途径基本前体，干扰该途径，抑制细菌DNA合成。

Packaging

5G,25G,100G

Other Notes

保持容器密闭，置于干燥通风处。置于干燥处。

pictograms

GHS08,GHS07

signalword

Warning

hcodes

H302,H361d

pcodes

P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000527337

0000503486

0000491347

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Spatiotemporal refinement of signal flow through association cortex during learning.

Ariel Gilad et al.

Nature communications, 11(1), 1744-1744 (2020-04-10)

Association areas in neocortex encode novel stimulus-outcome relationships, but the principles of their engagement during task learning remain elusive. Using chronic wide-field calcium imaging, we reveal two phases of spatiotemporal refinement of layer 2/3 cortical activity in mice learning whisker-based

Listeria monocytogenes strains selected on ciprofloxacin or the disinfectant benzalkonium chloride exhibit reduced susceptibility to ciprofloxacin, gentamicin, benzalkonium chloride, and other toxic compounds.

Mira Rakic-Martinez et al.

Applied and environmental microbiology, 77(24), 8714-8721 (2011-10-18)

Listeria monocytogenes is a leading agent for severe food-borne illness and death in the United States and other nations. Even though drug resistance has not yet threatened therapeutic interventions for listeriosis, selective pressure associated with exposure to antibiotics and disinfectants

A critical role for CD8 T cells in a nonhuman primate model of tuberculosis.

Crystal Y Chen et al.

PLoS pathogens, 5(4), e1000392-e1000392 (2009-04-22)

The role of CD8 T cells in anti-tuberculosis immunity in humans remains unknown, and studies of CD8 T cell-mediated protection against tuberculosis in mice have yielded controversial results. Unlike mice, humans and nonhuman primates share a number of important features

Intercontinental dissemination of azithromycin-resistant shigellosis through sexual transmission: a cross-sectional study.

Kate S Baker et al.

The Lancet. Infectious diseases, 15(8), 913-921 (2015-05-06)

Shigellosis is an acute, severe bacterial colitis that, in high-income countries, is typically associated with travel to high-risk regions (Africa, Asia, and Latin America). Since the 1970s, shigellosis has also been reported as a sexually transmitted infection in men who

Trimethoprim/sulfonamide combinations in the horse: a review.

E Van Duijkeren et al.

Journal of veterinary pharmacology and therapeutics, 17(1), 64-73 (1994-02-01)

The indications for use, side-effects, and pharmacokinetic parameters of trimethoprim, sulfonamides and their combinations in the horse are reviewed. Trimethoprim/sulfonamide (TMPS) combinations are used for the treatment of various diseases caused by gram-positive and gram-negative bacteria, including infections of the

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全球贸易项目编号

货号	GTIN
T7883-100G	04061837378706
T7883-25G	04061835514304
T7883-5G	04061835550319

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

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甲氧苄啶

≥98.5%

选择尺寸

关于此项目

主要文件

属性

Quality Level

assay

form

storage condition

color

antibiotic activity spectrum

mode of action

storage temp.

SMILES string

InChI

InChI key

Gene Information

相关类别

说明

General description

Application

Biochem/physiol Actions

Packaging

Other Notes

安全信息

pictograms

signalword

hcodes

pcodes

Hazard Classifications

存储类别

wgk

flash_point_f

flash_point_c

ppe

文件

分析证书(COA)

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