T9567
Thiolactomycin
98% (HPLC), solid
别名:
(5R)-4-Hydroxy-3,5-dimethyl-5-[(1E)-2-methyl-1,3-butadienyl]-2(5H)-thiophenone, Antibiotic 2-200, [R-(E)]-4-Hydroxy-3,5-dimethyl-5-(2-methyl-1,3-butadienyl)-2(5H)-thiophenone
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关于此项目
经验公式（希尔记法）:
C11H14O2S
化学文摘社编号:
分子量:
210.29
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
assay
98% (HPLC)
form
solid
color
light yellow
solubility
DMSO: soluble ~21 mg/mL, H2O: insoluble
SMILES string
C\C(C=C)=C/[C@@]1(C)SC(=O)C(C)=C1O
Gene Information
human ... FASN(2194)
Biochem/physiol Actions
Inhibitor of bacterial myristate synthesis. Does not inhibit eukaryotic myristate synthesis; antibiotic; antitrypanosomal. Shown to be effective against human sleeping sickness parasite, Trypanosoma brucei, as well as malaria parasite and toxoplasma.
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Simon M Jones et al.
Journal of medicinal chemistry, 48(19), 5932-5941 (2005-09-16)
Analogues of the natural antibiotic thiolactomycin (TLM), an inhibitor of the condensing reactions of type II fatty acid synthase, were synthesized and evaluated for their ability to inhibit the growth of the malaria parasite Plasmodium falciparum. Alkylation of the C4
John G Ondeyka et al.
Journal of natural products, 69(3), 377-380 (2006-03-28)
Fatty acids are essential for bacterial growth and viability, with the type II fatty acid synthesis (FAS II) pathway being a potential antibacterial target. A new, selective, and highly sensitive whole cell-based antisense strategy has been designed to screen for
S Sato et al.
Current topics in microbiology and immunology, 295, 251-273 (2005-11-04)
Determined efforts are being made to explore the non-photosynthetic plastid organelle of Plasmodium falciparum as a target for drug development. Certain antibiotics that block organellar protein synthesis are already in clinical use as antimalarials. However, all the indications are that
M L Merrill L Schaeffer et al.
Tuberculosis (Edinburgh, Scotland), 84(6), 353-360 (2004-11-05)
Tuberculosis remains a global health problem, and programs dedicated to discovery of novel compounds against Mycobacterium tuberculosis require robust assays for high-throughput screening of chemical and natural product libraries. Enzymes involved in the biosynthesis of mycolic acids, vital components of
Sudharsan Sridharan et al.
Journal of molecular biology, 366(2), 469-480 (2006-12-19)
Mycolic acids are long chain alpha-alkyl branched, beta-hydroxy fatty acids that represent a characteristic component of the Mycobacterium tuberculosis cell wall. Through their covalent attachment to peptidoglycan via an arabinogalactan polysaccharide, they provide the basis for an essential outer envelope
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