A0152
4-氨基吡啶
≥98%
别名:
4-吡啶胺, 4AP, 对氨基吡啶, 氨吡啶
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关于此项目
经验公式（希尔记法）:
C5H6N2
化学文摘社编号:
分子量:
94.11
EC Number:
207-987-9
UNSPSC Code:
12352200
MDL number:
Beilstein/REAXYS Number:
105782
InChI
1S/C5H6N2/c6-5-1-3-7-4-2-5/h1-4H,(H2,6,7)
InChI key
NUKYPUAOHBNCPY-UHFFFAOYSA-N
SMILES string
Nc1ccncc1
assay
≥98%
bp
273 °C (lit.)
mp
155-158 °C (lit.)
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Biochem/physiol Actions
Non-selective K+ channel blocker; reverses saxitoxin- and tetrodotoxin-induced cardiorespiratory depression; increases stimulation-induced release of acetylcholine; induces depolarization of GABA neurons.
signalword
Danger
Hazard Classifications
Acute Tox. 2 Oral - Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Aquatic Chronic 2 - Eye Dam. 1 - Skin Corr. 1B
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
312.8 °F
flash_point_c
156 °C
法规信息
新产品
此项目有
G N Tseng
The Journal of pharmacology and experimental therapeutics, 290(2), 569-577 (1999-07-20)
4-Aminopyridine (4AP) binding to rKv1.4 occurs preferentially in the activated state, whereas binding to rKv4.2 occurs in the rested state. To explore structural basis for the different state dependencies of 4AP binding, regions of rKv1.4 that are likely to form
V Armand et al.
Brain research, 841(1-2), 62-69 (1999-11-05)
Patients with absence epilepsy frequently develop convulsions later in life. We were therefore interested whether tissue from rats with a genetic absence epilepsy is more prone to seizure generation than normal animals. We compared the epileptiform activities induced by 4-aminopyridine
S A Doggrell et al.
Naunyn-Schmiedeberg's archives of pharmacology, 360(3), 317-323 (1999-10-30)
The effects of the outward rectifying potassium channel blocker, 4-aminopyridine, on contractile tone and on contractile responses to the spasmogens, 5-hydroxytryptamine and endothelin-1, were examined in pulmonary arteries (main and intralobar) and systemic vessels (aorta and mesenteric artery) from rats
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