方案
≥98%
沸点
273 °C (lit.)
mp
155-158 °C (lit.)
SMILES字符串
Nc1ccncc1
InChI
1S/C5H6N2/c6-5-1-3-7-4-2-5/h1-4H,(H2,6,7)
InChI key
NUKYPUAOHBNCPY-UHFFFAOYSA-N
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生化/生理作用
Non-selective K+ channel blocker; reverses saxitoxin- and tetrodotoxin-induced cardiorespiratory depression; increases stimulation-induced release of acetylcholine; induces depolarization of GABA neurons.
警示用语：
Danger
危险分类
Acute Tox. 2 Oral - Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Aquatic Chronic 2 - Eye Dam. 1 - Skin Corr. 1B
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
闪点(°F)
312.8 °F
闪点(°C)
156 °C
法规信息
新产品
G N Tseng
The Journal of pharmacology and experimental therapeutics, 290(2), 569-577 (1999-07-20)
4-Aminopyridine (4AP) binding to rKv1.4 occurs preferentially in the activated state, whereas binding to rKv4.2 occurs in the rested state. To explore structural basis for the different state dependencies of 4AP binding, regions of rKv1.4 that are likely to form
S A Doggrell et al.
Naunyn-Schmiedeberg's archives of pharmacology, 360(3), 317-323 (1999-10-30)
The effects of the outward rectifying potassium channel blocker, 4-aminopyridine, on contractile tone and on contractile responses to the spasmogens, 5-hydroxytryptamine and endothelin-1, were examined in pulmonary arteries (main and intralobar) and systemic vessels (aorta and mesenteric artery) from rats
V Armand et al.
Brain research, 841(1-2), 62-69 (1999-11-05)
Patients with absence epilepsy frequently develop convulsions later in life. We were therefore interested whether tissue from rats with a genetic absence epilepsy is more prone to seizure generation than normal animals. We compared the epileptiform activities induced by 4-aminopyridine
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