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Merck
CN

A0362

Adjuplex佐剂 疫苗

Concentrate, sterile

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NACRES:
NA.25
UNSPSC Code:
12352200
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sterility

sterile

quality

NOT FOR HUMAN USE

shipped in

wet ice

storage temp.

2-8°C

General description

佐剂可增强对疫苗的免疫反应而无反应原性,并且已证明优于明矾、弗氏佐剂、Ribi-R730和许多其他实验佐剂。在实验动物中,已证明Adjuplex可改善对多种实验性人类疫苗(包括HIV,流感,轮状病毒和疟疾)的保护性免疫应答。

Application

佐剂适用于所有类型的抗原,例如整个生物体(存活或灭活)、蛋白质、多糖、DNA、病毒载体和VLP。它适用于所有给药途径,包括肌内、皮下、真皮内和粘膜(包括鼻内)。
佐剂 疫苗佐剂已被用于研究佐剂对 DNA 疫苗接种的影响。

Preparation Note

1ml 的佐剂足以配制十支0.5ml的疫苗。

Other Notes

Adjuplex 疫苗佐剂是一种非变性佐剂,不含油、清洁剂、防腐剂或动物或细菌来源的成分。佐剂为非免疫原性,不含过敏原,酶,汞,铝和其他金属。

Legal Information

Adjuplex is a trademark of Advanced BioAdjuvants, LLC

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Warning

hcodes

Hazard Classifications

Eye Irrit. 2

存储类别

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


历史批次信息供参考:

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Cornelis J M Melief
Journal of immunotherapy (Hagerstown, Md. : 1997), 35(3), 215-216 (2012-03-17)
Here, we review a novel vaccine modality, characterized by the administration of long (23 to 45 amino acids) synthetic peptides in incomplete Freund's adjuvant (mineral oil based, Montanide ISA-51), delivered subcutaneously. Such vaccines were first demonstrated to be much more
Jane E Libbey et al.
Vaccine, 29(17), 3356-3362 (2010-09-21)
Experimental autoimmune encephalomyelitis (EAE) is an experimental model for multiple sclerosis. EAE can be induced by inoculation with central nervous system (CNS) proteins or peptides emulsified in complete Freund's adjuvant. Protection from EAE, enhancement of EAE or subclinical priming for
Production of EV71 vaccine candidates.
Chong P, Hsieh SY, Liu CC, et al.
Human Vaccines & Immunotherapeutics, 8 (2012)
Samantha Burton et al.
Journal of virology, 93(7) (2019-01-18)
The goals of preclinical HIV vaccine studies in nonhuman primates are to develop and test different approaches for their ability to generate protective immunity. Here, we compared the impact of 7 different vaccine modalities, all expressing the HIV-1 1086.C clade
Rui Kong et al.
Cell, 178(3), 567-584 (2019-07-28)
The vaccine-mediated elicitation of antibodies (Abs) capable of neutralizing diverse HIV-1 strains has been a long-standing goal. To understand how broadly neutralizing antibodies (bNAbs) can be elicited, we identified, characterized, and tracked five neutralizing Ab lineages targeting the HIV-1-fusion peptide

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