A0479
Adrafinil
≥98% (HPLC), solid
别名:
2-[(Diphenylmethyl)sulfinyl]acetohydroxamic acid, CRL 40028, Olmifon
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关于此项目
经验公式（希尔记法）:
C15H15NO3S
化学文摘社编号:
分子量:
289.35
UNSPSC Code:
12352200
PubChem Substance ID:
EC Number:
264-303-1
MDL number:
InChI key
CGNMLOKEMNBUAI-UHFFFAOYSA-N
InChI
1S/C15H15NO3S/c17-14(16-18)11-20(19)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15,18H,11H2,(H,16,17)
SMILES string
ONC(=O)CS(=O)C(c1ccccc1)c2ccccc2
assay
≥98% (HPLC)
form
solid
storage condition
desiccated
color
white
solubility
DMSO: 35 mg/mL
Biochem/physiol Actions
Agent promoting wakefulness; analog of Modafinil.
Disclaimer
Hygroscopic
signalword
Warning
hcodes
pcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
R Nageswara Rao et al.
Biomedical chromatography : BMC, 23(8), 811-816 (2009-04-09)
A simple and rapid normal-phase HPLC method for enantiospecific separation of a psychostimulant, adrafinil (ADL), and its metabolite modafinil (MDL) in rat serum and urine was developed. The separation was accomplished on a normal-phase polysaccharide stationary phase Chiralcel OJ-H using
M Hascoet et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 5(4), 481-489 (1995-12-01)
The binding and locomotor profile of a new sigma ligand, S14905, (isobutyl-N-(1-indan-2yl-piperid-4-yl)N-methyl carbamate, furamate) was studied. The binding data revealed that S14905 has a high affinity for sigma receptors and very low affinity for both dopamine D1 and D2 receptors.
F Lechin et al.
Journal of medicine, 31(5-6), 333-361 (2001-08-18)
Neurochemical, neuroautonomic and neuropharmacological assessments carried out on all our myasthenia gravis (MG) patients showed that they presented a neural sympathetic deficit plus excessive adrenal-sympathetic activity. These abnormalities were registered during the basal (supine-resting) state, as well as after several
C Rozé et al.
Archives internationales de pharmacodynamie et de therapie, 265(1), 119-127 (1983-09-01)
The drug CRL 40 028 increases spontaneous motility through an action on central adrenergic receptors. The effects of this drug have been tested in rats on the external pancreatic secretion induced by secretin, CCK, acetylcholine, vagal electrical stimulation or 2
A Delini-Stula et al.
Psychopharmacology, 101(1), 62-66 (1990-01-01)
Acute (10 or 20 mg/kg IP) and subchronic (2 x 5 or 10 mg/kg IP daily for 7 days) effects of desipramine, imipramine, maprotiline, (+)- and (-)-oxaprotiline enantiomers as well as selective 5-HT-uptake inhibitors citalopram and ifoxetine on yawning, induced
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