生化/生理作用
Activin receptor IA/Fc chimera does not bind directly to activin or inhibin but will associate with the type II receptor-activin complex and initiate signal transduction. Activin isoforms are members of the TGF-β superfamily that bind to heteromeric complexes of type I and type II serine/threonine kinase receptors, both of which are essential for signal transduction. Human, murine, and bovine type IA activin receptors demonstrate greater than 98% homology.
外形
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
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L Attisano et al.
Molecular and cellular biology, 16(3), 1066-1073 (1996-03-01)
Activin exerts its effects by simultaneously binding to two types of p rotein serine/threonine kinase receptors, each type existing in various isoforms. Using the ActR-IB and ActR-IIB receptor isoforms, we have investigated the mechanism of activin receptor activation. ActR-IIB are
Yong-Gil Kim et al.
Arthritis & rheumatology (Hoboken, N.J.), 66(10), 2793-2803 (2014-07-02)
Although ankylosing spondylitis (AS) is driven by immune-mediated processes, little is known about the presence and role of autoantibodies in this disease. This study was undertaken to investigate whether autoantibodies occur in and are involved in AS. We performed human
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