生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
PBS solution
分子量
antigen ~50 kDa
种属反应性
mouse, human, chicken
技术
indirect immunofluorescence: 1:100 using cultured human HeLa cells
microarray: suitable
western blot: 1:250 using a nuclear extract from HeLa human carcinoma cells
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... TFAP2A(7020)
一般描述
Activation Protein transcription factor 2 (AP-2) is a developmentally modulated transcription factor that binds to specific sequence such as CCCCAGGC or related sequences. These sequences are usually present in several promoter and enhancer gene regions, including the promoters of the AP-2 genes themselves,,. AP-2 expression has also been linked to human breast cancer cells.
By immunoblotting, rabbit anti-AP-2α reacts specifically with human AP-2α. The sequence recognized by the antibody differs from the corresponding mouse sequence by one residue and from the chicken sequence by 2 residues.
By immunoblotting, rabbit anti-AP-2α reacts specifically with human AP-2α. The sequence recognized by the antibody differs from the corresponding mouse sequence by one residue and from the chicken sequence by 2 residues.
免疫原
synthetic peptide corresponding to human AP-2α, C-terminal sequence, (amino acids 420-437) conjugated to KLH with glutaraldehyde.
应用
Rabbit anti-AP-2alpha antibody can be used for western blot (1:250), microarray and indirect immunofluorescence (1:100) assays.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
B C Turner et al.
Cancer research, 58(23), 5466-5472 (1998-12-16)
The AP-2 transcription factors are required for normal growth and morphogenesis during mammalian development. Previous in vitro studies have also indicated that the AP-2 family of proteins may be involved in the etiology of human breast cancer. The AP-2 genes
N Mohibullah et al.
Nucleic acids research, 27(13), 2760-2769 (1999-06-22)
The AP-2 family of transcription factors are defined by the presence of a novel DNA binding domain, termed a 'basic helix-span-helix' motif. The AP-2 genes regulate important aspects of vertebrate embryogenesis and have also been linked to the control of
B Lüscher et al.
Genes & development, 3(10), 1507-1517 (1989-10-01)
The expression of the transcription factor AP-2 recently has been shown to be enhanced during retinoic acid (RA)-induced differentiation of NT2 cells, a human teratocarcinoma cell line. Here we show that this induction of AP-2 mRNA is at the level
Marie Ennen et al.
Free radical biology & medicine, 50(12), 1771-1779 (2011-03-23)
A high basal expression of manganese superoxide dismutase (MnSOD) has been reported in aggressive breast cancer cells, according to an unknown mechanism, and contributes to their invasive abilities. Here, we report the involvement of Sp1 and nuclear factor-κB (NF-κB) transcription
T Williams et al.
Genes & development, 5(4), 670-682 (1991-04-01)
The mammalian transcription factor AP-2 is a sequence-specific DNA-binding protein expressed in neural crest lineages and regulated by retinoic acid. Here we report a structure/function analysis of the DNA-binding and transcription activation properties of the AP-2 protein. DNA contact studies
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