A1346
ASB-14
别名:
3-[N,N-二甲基（3-肉豆蔻酰氨丙基）氨] 丙磺酸盐, 氨基磺基甜菜碱-14
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关于此项目
经验公式（希尔记法）:
C22H46N2O4S
化学文摘社编号:
分子量:
434.68
UNSPSC Code:
12161902
NACRES:
NA.28
MDL number:
SMILES string
[S](=O)(=O)([O-])CCC[N+](CCCNC(=O)CCCCCCCCCCCCC)(C)C
InChI
1S/C22H46N2O4S/c1-4-5-6-7-8-9-10-11-12-13-14-17-22(25)23-18-15-19-24(2,3)20-16-21-29(26,27)28/h4-21H2,1-3H3,(H-,23,25,26,27,28)
InChI key
UTSXERRKRAEDOV-UHFFFAOYSA-N
description
zwitterionic
assay
≥95.0% (HPLC)
form
powder
mol wt
average mol wt >10,000
aggregation number
≥23
storage temp.
2-8°C
Quality Level
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Application
两性离子洗涤剂。用于 2D 电泳时溶解蛋白质（包括膜蛋白）。
ASB-14 用作再水合缓冲液成分，用于制备来自杜氏利什曼原虫（ Leishmania donovani）的蛋白组学样品。
Biochem/physiol Actions
ASB-14可用于蛋白酶体提取，特别适用膜相关蛋白。与CHAPS（3-（3-胆酰胺基丙基）二甲基铵基）-1-丙烷磺酸盐一起，用于蛋白增溶，即使在硫脲存在的情况下，也可以起作用。
General description
ASB-14包含尾部烷基基团和头部氨基磺基甜菜碱基团。
Analysis Note
ASB-14（脒基磺基甜菜碱-14）是一种膜增溶两性离子洗涤剂（中链脒基磺基甜菜碱表面活性剂），可用于蛋白质和大分子研究，用于蛋白质的制备提取和增溶，以通过 2D-电泳等方法进行分离和分析。ASB-14 有望在组织工程中用于异种支架材料的去抗原 (AR) 制备。ASB-14 可用于开发和研究两性离子胶束。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Francisella t ularensis Proteome: Low Levels of ASB-14 Facilitate the Visualization of Membrane Proteins in Total Protein Extracts
Twine SM, et al.
Journal of Proteome Research, 4(5), 1848-1854 (2005)
Nityakalyani Srinivas et al.
Science (New York, N.Y.), 327(5968), 1010-1013 (2010-02-20)
Antibiotics with new mechanisms of action are urgently required to combat the growing health threat posed by resistant pathogenic microorganisms. We synthesized a family of peptidomimetic antibiotics based on the antimicrobial peptide protegrin I. Several rounds of optimization gave a
M P Molloy et al.
Electrophoresis, 22(9), 1686-1696 (2001-06-27)
Many bacterial outer membrane proteins (OMPs) are missing from two-dimensional (2-D) gel proteome maps. Recently, we developed a technique for 2-D electrophoresis (2-DE) of Escherichia coli OMPs using alkaline pH incubation for isolation of OMPs, followed by improved solubilization conditions
Thermodynamic and structural characterization of zwitterionic micelles of the membrane protein solubilizing amidosulfobetaine surfactants ASB-14 and ASB-16
D Andrea MG, et al.
Langmuir, 27(13), 8248-8256 (2011)
Manabu Minami et al.
The Journal of biological chemistry, 283(15), 9692-9703 (2008-02-14)
Macrophage activation participates pivotally in the pathophysiology of chronic inflammatory diseases, including atherosclerosis. Through the receptor EP4, prostaglandin E(2) (PGE(2)) exerts an anti-inflammatory action in macrophages, suppressing stimulus-induced expression of certain proinflammatory genes, including chemokines. We recently identified a novel
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