A1612
AF-353 hydrochloride
≥98% (HPLC), powder
别名:
5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2,4-pyrimidinediamine hydrochloride, Ro 4 hydrochloride
assay
≥98% (HPLC)
form
powder
color
off-white to light brown
solubility
DMSO: >10 mg/mL
originator
Roche
storage temp.
2-8°C
SMILES string
Cl.COc1cc(C(C)C)c(Oc2cnc(N)nc2N)cc1I
Biochem/physiol Actions
AF-353 is a P2X3, P2X2/3 antagonist.
AF-353 is a potent antagonist of P2X3 homotrimers and P2X2/3 heterotrimers with a pIC50 range of 7.3 - 8.5. The compound does not affect other P2X family members at 300-fold excess concentrations. AF-353 significantly reversed pain behavior in a rat model of bone cancer pain.
Features and Benefits
This compound is featured on the P2 Receptors: P2X Ion Channel Family page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持