A1625
乙酰乙酰辅酶 A 钠盐 水合物
cofactor for acyl transfer
别名:
乙酰乙酰-CoANa3
生物来源
synthetic (Organic)
质量水平
方案
≥90%
表单
powder
溶解性
H2O: soluble~-50 g/L
储存温度
−20°C
SMILES字符串
[Na+].[Na+].[Na+].CC(=O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP([O-])(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP([O-])([O-])=O)n2cnc3c(N)ncnc23
InChI
1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t14-,18-,19-,20+,24-/m1/s1
InChI key
OJFDKHTZOUZBOS-CITAKDKDSA-N
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应用
乙酰乙酰-CoA硫解酶EC 2.3.1.9的底物；在无活菌素的生物合成中发挥作用。
乙酰乙酰辅酶A（乙酰乙酰-CoA）可用作许多酶的底物，包括：在反向缩合反应中产生乙酰辅酶A的乙酰乙酰-CoA硫解酶（EC2.3.1），以及在甲羟戊酸途径中产生3-羟基-3-甲基戊二酰（HMG）辅酶A并导致萜类化合物生物合成的（3-羟基-3-甲基戊二酰辅酶A（CoA）合成酶（HMGCS））。 乙酰乙酰-CoA也是微生物中聚-β-羟基丁酸酯聚合物的前体。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Rongcan Luo et al.
Signal transduction and targeted therapy, 6(1), 325-325 (2021-09-02)
Alzheimer's disease (AD) is characterized by progressive synaptic dysfunction, neuronal death, and brain atrophy, with amyloid-β (Aβ) plaque deposits and hyperphosphorylated tau neurofibrillary tangle accumulation in the brain tissue, which all lead to loss of cognitive function. Pathogenic mutations in
Tamay Seker et al.
Applied microbiology and biotechnology, 67(1), 119-124 (2004-09-28)
The mevalonate pathway plays an important role in providing the cell with a number of essential precursors for the synthesis of biomass constituents. With respect to their chemical structure, the metabolites of this pathway can be divided into two groups:
Clementina Dellomonaco et al.
Nature, 476(7360), 355-359 (2011-08-13)
Advanced (long-chain) fuels and chemicals are generated from short-chain metabolic intermediates through pathways that require carbon-chain elongation. The condensation reactions mediating this carbon-carbon bond formation can be catalysed by enzymes from the thiolase superfamily, including β-ketoacyl-acyl-carrier protein (ACP) synthases, polyketide
Werner J Kovacs et al.
Progress in lipid research, 41(5), 369-391 (2002-07-18)
Peroxisomes contain enzymes catalyzing a number of indispensable metabolic functions mainly related to lipid metabolism. The importance of peroxisomes in man is stressed by the existence of genetic disorders in which the biogenesis of the organelle is defective, leading to
James J Truglio et al.
The Journal of biological chemistry, 278(43), 42352-42360 (2003-08-12)
Bacterial enzymes of the menaquinone (Vitamin K2) pathway are potential drug targets because they lack human homologs. MenB, 1,4-dihydroxy-2-naphthoyl-CoA synthase, the fourth enzyme in the biosynthetic pathway leading from chorismate to menaquinone, catalyzes the conversion of O-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA
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