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A1709

Adrenocorticotropic Hormone Fragment 1-10 human, rat

≥97% (HPLC)

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关于此项目

经验公式（希尔记法）:
C59H78N16O16S
化学文摘社编号:
2791-05-1
分子量:
1299.41
UNSPSC Code:
12352200
PubChem Substance ID:
24890477
MDL number:
MFCD00133029
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assay

≥97% (HPLC)

form

powder

color

white

UniProt accession no.

P01189, P01194

storage temp.

−20°C

SMILES string

CSCCC(NC(=O)C(CO)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(N)CO)C(=O)NC(CCC(O)=O)C(=O)NC(Cc2cnc[nH]2)C(=O)NC(Cc3ccccc3)C(=O)NC(CCCNC(N)=N)C(=O)NC(Cc4c[nH]c5ccccc45)C(=O)NCC(O)=O

InChI

1S/C59H78N16O16S/c1-92-21-19-42(70-58(91)47(30-77)75-56(89)43(71-50(83)38(60)29-76)23-33-13-15-36(78)16-14-33)54(87)69-41(17-18-48(79)80)53(86)74-46(25-35-27-63-31-67-35)57(90)72-44(22-32-8-3-2-4-9-32)55(88)68-40(12-7-20-64-59(61)62)52(85)73-45(51(84)66-28-49(81)82)24-34-26-65-39-11-6-5-10-37(34)39/h2-6,8-11,13-16,26-27,31,38,40-47,65,76-78H,7,12,17-25,28-30,60H2,1H3,(H,63,67)(H,66,84)(H,68,88)(H,69,87)(H,70,91)(H,71,83)(H,72,90)(H,73,85)(H,74,86)(H,75,89)(H,79,80)(H,81,82)(H4,61,62,64)

InChI key

DIBOMWBTHPDGOJ-UHFFFAOYSA-N

Gene Information

human ... POMC(5443)
rat ... Pomc(24664)

Application

Adrenocorticotropic Hormone Fragment 1-10 [ACTH(1-10)] is used as a model peptide to study the the suitability of various mimic structures to make micelle models of biological membranes.

Biochem/physiol Actions

Facilitates avoidance acquisition. Lacks adrenocorticotropic activity.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

存储类别

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
1417959
048K0723
046K1225
046K1340
112K1525

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Tuck C Wong et al.
Journal of biomolecular structure & dynamics, 20(1), 39-57 (2002-07-30)
The structure and interactions of the 1-24 fragment of the adrenocorticotropin hormone, ACTH (1-24), with membrane have been studied by molecular dynamics (MD) simulation in an NPT ensembles in two explicit membrane mimics, a dodecylphosphocholine (DPC) micelle and a dimyristoylphosphatidylcholine
Molecular dynamics simulation of adrenocorticotropin (1-10) peptide in a solvated dodecylphosphocholine micelle.
Gao X, Wong TC.
Biopolymers, 58, 6430659-6430659 (2001)
M D Gomar et al.
Experientia, 51(3), 209-212 (1995-03-15)
In this study, we examined the effect of intracerebroventricular (i.c.v) injection of melatonin and/or ACTH1-10 and ACTH4-10 on [3H]flunitrazepam binding sites in the cerebral cortex of hypophysectomized rats. Hypophysectomy increased the Bmax (maximum number of binding sites) of benzodiazepine (BNZ)
T Wymore et al.
Journal of biomolecular structure & dynamics, 18(3), 461-476 (2001-01-10)
ACTH (1-10), an adrenocorticotropin hormone fragment, was studied by molecular dynamics (MD) simulation in the NPT ensemble in an explicit sodium dodecylsulfate (SDS) micelle. Initially, distance restraints derived from NMR nuclear Overhauser enhancements were incorporated during the equilibration stage of
M J Hoogduijn et al.
Biochemical and biophysical research communications, 290(2), 844-850 (2002-01-12)
The melanocortins are involved in the regulation of various cognitive and physiological processes such as learning, feeding, immune suppression, pigmentation, and sebum production. Five melanocortin receptors have been identified, of which the melanocortin 5 receptor (MC5R) has the most widespread

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