A1733
AMPK (α2/β1/γ1), active, His tagged human
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
别名:
AMK2, AMPKG, HAMPKb, MGC17785, MGC8666, PRKAA2, PRKAB1, PRKAG1
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关于此项目
NACRES:
NA.32
UNSPSC Code:
12352202
Specific activity:
230-311 nmol/min·mg
Assay:
≥70% (SDS-PAGE)
Recombinant:
expressed in baculovirus infected Sf9 cells
recombinant
expressed in baculovirus infected Sf9 cells
Quality Level
product line
PRECISIO® Kinase
assay
≥70% (SDS-PAGE)
form
buffered aqueous glycerol solution
specific activity
230-311 nmol/min·mg
mol wt
A2 subunit ~69 kDa, B1 subunit ~38 kDa, G1 subunit ~40 kDa
relevant disease(s)
diabetes
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... PRKAA2(5563), PRKAB1(5564), PRKAG1(5571)
Biochem/physiol Actions
AMPK (A2/B1/G1) plays a key role in insulin signaling pathway and is a major therapeutic target for the treatment of diabetes. AMPK is viewed as a fuel sensor for glucose and lipid metabolism by modulating the activity of the autonomous nervous system in vivo. Short-term overexpression of a constitutively active form of AMPK in the liver leads to mild hypoglycemia and fatty liver due to increased fatty acid utilization.
Physical form
Supplied in 50 mM sodium phosphate, pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.25 mM DTT, 25% glycerol.
Legal Information
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
法规信息
常规特殊物品
此项目有
Marc Foretz et al.
Diabetes, 54(5), 1331-1339 (2005-04-28)
AMP-activated protein kinase (AMPK) is a major therapeutic target for the treatment of diabetes. We investigated the effect of a short-term overexpression of AMPK specifically in the liver by adenovirus-mediated transfer of a gene encoding a constitutively active form of
B Viollet et al.
Biochemical Society transactions, 31(Pt 1), 216-219 (2003-01-28)
AMP-activated protein kinase (AMPK) is viewed as a fuel sensor for glucose and lipid metabolism. To understand better the physiological role of the catalytic AMPK subunit isoforms, we generated two knockout mouse models with the alpha1 (AMPK alpha 1(-/-)) and
Yanan Wang et al.
Nature communications, 13(1), 7215-7215 (2022-11-27)
Tumour cell metabolic plasticity is essential for tumour progression and therapeutic responses, yet the underlying mechanisms remain poorly understood. Here, we identify Prospero-related homeobox 1 (PROX1) as a crucial factor for tumour metabolic plasticity. Notably, PROX1 is reduced by glucose
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| A1733-10UG | 04061837749803 |
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