A1757
6-氮杂嘧啶
≥98%, powder
别名:
6-AU, 1,2,4-三嗪-3,5(2H,4H)-二酮, 3,5-二羟基-1,2,4-三嗪, 6-氮杂-2,4-二羟基嘧啶
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关于此项目
经验公式（希尔记法）:
C3H3N3O2
化学文摘社编号:
分子量:
113.07
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
207-318-0
MDL number:
Beilstein/REAXYS Number:
116472
Assay:
≥98%
Form:
powder
Solubility:
1 M NH4OH: 50 mg/mL, clear to slightly hazy, colorless to light yellow-green
Application
6-氮杂尿嘧啶已用作转录抑制剂，用于研究其对终止和多聚腺苷酸化蛋白(Tpa1)和Mag1缺失细胞的活力影响。它还已用作基础培养基中的乳清酸核苷-5′-单磷酸脱羧酶(OMP脱羧酶)抑制剂，用于测定OMP脱羧酶活性。
Biochem/physiol Actions
6-氮杂尿嘧啶(6-AU)是尿嘧啶的嘧啶类似物，具有抗肿瘤活性。它可用于去除细胞内的鸟苷三磷酸(GTP)和尿苷三磷酸(UTP)两种核苷酸混合物，从而抑制各种微生物生长。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Kazuko Matsubara et al.
Genes to cells : devoted to molecular & cellular mechanisms, 12(1), 13-33 (2007-01-11)
The core histones are essential components of the nucleosome that act as global negative regulators of DNA-mediated reactions including transcription, DNA replication and DNA repair. Modified residues in the N-terminal tails are well characterized in transcription, but not in DNA
Peter L Freddolino et al.
eLife, 7 (2018-04-06)
Cells adapt to familiar changes in their environment by activating predefined regulatory programs that establish adaptive gene expression states. These hard-wired pathways, however, may be inadequate for adaptation to environments never encountered before. Here, we reveal evidence for an alternative
Rahul V Nene et al.
PLoS genetics, 14(1), e1007170-e1007170 (2018-01-11)
Defects in the genes encoding the Paf1 complex can cause increased genome instability. Loss of Paf1, Cdc73, and Ctr9, but not Rtf1 or Leo1, caused increased accumulation of gross chromosomal rearrangements (GCRs). Combining the cdc73Δ mutation with individual deletions of
Clinical studies of 6-azauracil
Shnider BI, et al.
Cancer Research, 20(1), 28-33 (1960)
Hai-Ning Du et al.
Genes & development, 22(20), 2786-2798 (2008-10-17)
Set2-mediated H3 K36 methylation is an important histone modification on chromatin during transcription elongation. Although Set2 associates with the phosphorylated C-terminal domain (CTD) of RNA polymerase II (RNAPII), the mechanism of Set2 binding to chromatin and subsequent exertion of its
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