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经验公式(希尔记法):
C3H3N3O2
化学文摘社编号:
分子量:
113.07
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
207-318-0
MDL number:
Beilstein/REAXYS Number:
116472
Assay:
≥98%
Form:
powder
Solubility:
1 M NH4OH: 50 mg/mL, clear to slightly hazy, colorless to light yellow-green
产品名称
6-氮杂嘧啶, ≥98%
Quality Level
assay
≥98%
form
powder
mp
274-275 °C (lit.)
solubility
1 M NH4OH: 50 mg/mL, clear to slightly hazy, colorless to light yellow-green
SMILES string
O=C1NN=CC(=O)N1
InChI
1S/C3H3N3O2/c7-2-1-4-6-3(8)5-2/h1H,(H2,5,6,7,8)
InChI key
SSPYSWLZOPCOLO-UHFFFAOYSA-N
Application
6-氮杂尿嘧啶已用作转录抑制剂,用于研究其对终止和多聚腺苷酸化蛋白(Tpa1)和Mag1缺失细胞的活力影响。它还已用作基础培养基中的乳清酸核苷-5′-单磷酸脱羧酶(OMP脱羧酶)抑制剂,用于测定OMP脱羧酶活性。
Biochem/physiol Actions
6-氮杂尿嘧啶(6-AU)是尿嘧啶的嘧啶类似物,具有抗肿瘤活性。它可用于去除细胞内的鸟苷三磷酸(GTP)和尿苷三磷酸(UTP)两种核苷酸混合物,从而抑制各种微生物生长。
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
相关内容
Product Information Sheet
Kazuko Matsubara et al.
Genes to cells : devoted to molecular & cellular mechanisms, 12(1), 13-33 (2007-01-11)
The core histones are essential components of the nucleosome that act as global negative regulators of DNA-mediated reactions including transcription, DNA replication and DNA repair. Modified residues in the N-terminal tails are well characterized in transcription, but not in DNA
Peter L Freddolino et al.
eLife, 7 (2018-04-06)
Cells adapt to familiar changes in their environment by activating predefined regulatory programs that establish adaptive gene expression states. These hard-wired pathways, however, may be inadequate for adaptation to environments never encountered before. Here, we reveal evidence for an alternative
Mihajlo Etinski et al.
Physical chemistry chemical physics : PCCP, 12(48), 15665-15671 (2010-08-04)
The photophysical properties of 6-azauracil were studied by means of ab initio quantum chemical methods. On the basis of our calculations we propose here the following mechanism for the lack of fluorescence and the high triplet quantum yield that was
全球贸易项目编号
| 货号 | GTIN |
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