A1757
6-氮杂嘧啶
≥98%, powder
别名:
6-AU, 1,2,4-三嗪-3,5(2H,4H)-二酮, 3,5-二羟基-1,2,4-三嗪, 6-氮杂-2,4-二羟基嘧啶
产品名称
6-氮杂嘧啶, ≥98%
方案
≥98%
表单
powder
mp
274-275 °C (lit.)
溶解性
1 M NH4OH: 50 mg/mL, clear to slightly hazy, colorless to light yellow-green
SMILES字符串
O=C1NN=CC(=O)N1
InChI
1S/C3H3N3O2/c7-2-1-4-6-3(8)5-2/h1H,(H2,5,6,7,8)
InChI key
SSPYSWLZOPCOLO-UHFFFAOYSA-N
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应用
6-氮杂尿嘧啶已用作转录抑制剂，用于研究其对终止和多聚腺苷酸化蛋白(Tpa1)和Mag1缺失细胞的活力影响。它还已用作基础培养基中的乳清酸核苷-5′-单磷酸脱羧酶(OMP脱羧酶)抑制剂，用于测定OMP脱羧酶活性。
生化/生理作用
6-氮杂尿嘧啶(6-AU)是尿嘧啶的嘧啶类似物，具有抗肿瘤活性。它可用于去除细胞内的鸟苷三磷酸(GTP)和尿苷三磷酸(UTP)两种核苷酸混合物，从而抑制各种微生物生长。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
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Genome engineering is a powerful approach to study how chromosomal architecture impacts phenotypes. However, quantifying the fitness impact of translocations independently from the confounding effect of base substitutions has so far remained challenging. We report a novel application of the
Allan Guiguen et al.
The EMBO journal, 26(6), 1552-1559 (2007-03-03)
Capping of nascent pre-mRNAs is thought to be a prerequisite for productive elongation and associated serine 2 phosphorylation of the C-terminal domain (CTD) of RNA polymerase II (PolII). The mechanism mediating this link is unknown, but is likely to include
Mattias Carlsson et al.
PloS one, 13(5), e0196840-e0196840 (2018-05-09)
Purine and pyrimidine analogues have important uses in chemotherapies against cancer, and a better understanding of the mechanisms that cause resistance to these drugs is therefore of importance in cancer treatment. In the yeast Saccharomyces cerevisiae, overexpression of the HAM1
Mihajlo Etinski et al.
Physical chemistry chemical physics : PCCP, 12(48), 15665-15671 (2010-08-04)
The photophysical properties of 6-azauracil were studied by means of ab initio quantum chemical methods. On the basis of our calculations we propose here the following mechanism for the lack of fluorescence and the high triplet quantum yield that was
Kostyantyn V Dmytruk et al.
Metabolic engineering, 13(1), 82-88 (2010-11-03)
Currently, the mutant of the flavinogenic yeast Candida famata dep8 isolated by classic mutagenesis and selection is used for industrial riboflavin production. Here we report on construction of a riboflavin overproducing strain of C. famata using a combination of random
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