A2112
Ac-PGP 三氟乙酸盐 水合物
≥98% (HPLC)
别名:
1-Acetyl-L-prolylglycyl-L-proline, Acetyl Pro-Gly-Pro, Acetyl-proline-glycine-proline, N-α-PGP, acPGP
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关于此项目
经验公式（希尔记法）:
C14H21N3O5 · xC2HF3O2 · yH2O
化学文摘社编号:
分子量:
311.33 (anhydrous free base basis)
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
shipped in
wet ice
InChI
1S/C14H21N3O5.C2HF3O2.H2O/c1-9(18)16-6-2-4-10(16)13(20)15-8-12(19)17-7-3-5-11(17)14(21)22;3-2(4,5)1(6)7;/h10-11H,2-8H2,1H3,(H,15,20)(H,21,22);(H,6,7);1H2/t10-,11-;;/m0../s1
SMILES string
O.OC(=O)C(F)(F)F.CC(=O)N1CCC[C@H]1C(=O)NCC(=O)N2CCC[C@H]2C(O)=O
InChI key
UCOFOXNKITYGTK-ULEGLUPFSA-N
assay
≥98% (HPLC)
form
powder
color
white to tan
solubility
deionized water: ≥2 mg/mL
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
Ac-PGP is a neutrophil chemoattractant.
N-acetyl Proline-Glycine-Proline (ac-PGP) is a potent and selective neutrophil chemoattractant. It is generated enzymatically from extracellular matrix proteins such as collagen. PGP is generated from native collagen by the action of matrix metalloproteinase–8 (MMP-8) and/or MMP-9, followed by a secondary cleavage by prolyl endopeptidase (PE). N-terminal acetylation of PGP (Ac-PGP) occurs through an unknown mechanism. Both PGP and AcPGP are considered biomarkers and possible therapeutic targets for chronic obstructive pulmonary disease (COPD) and may also be markers for acute pulmonary exacerbation in Cystic Fibrosis.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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