A263
ATPA
solid
别名:
(RS)-2-Amino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl)propanoic acid
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关于此项目
经验公式（希尔记法）:
C10H16N2O4
化学文摘社编号:
分子量:
228.25
MDL编号:
UNSPSC代码:
12352202
PubChem化学物质编号:
NACRES:
NA.77
表单
solid
质量水平
颜色
white
溶解性
DMSO: 10 mg/mL
H2O: 2.5 mg/mL
SMILES字符串
CC(C)(C)c1onc(O)c1CC(N)C(O)=O
InChI
1S/C10H16N2O4/c1-10(2,3)7-5(8(13)12-16-7)4-6(11)9(14)15/h6H,4,11H2,1-3H3,(H,12,13)(H,14,15)
InChI key
PIXJURSCCVBKRF-UHFFFAOYSA-N
基因信息
human ... GRIK1(2897)
rat ... Gria1(50592), Grik1(29559), Grin2a(24409)
相关类别
生化/生理作用
Selective kainate receptor agonist.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Xiaoye Liu et al.
Frontiers in cell and developmental biology, 8, 590-590 (2020-08-01)
Migration of neutrophils across endothelial barriers to capture and eliminate bacteria is served as the first line of innate immunity. Bacterial virulence factors damage endothelium to produce inflammatory cytokines interacts with neutrophils. However, the mechanisms that behind endothelial-neutrophil interaction impact
Mai Marie Nielsen et al.
Molecular pharmacology, 63(1), 19-25 (2002-12-19)
Only a few agonists exhibit selectivity between the AMPA and the kainate subtypes of the glutamate receptor. The most commonly used kainate receptor preferring agonist, (S)-2-amino-3-(5-tert-butyl-3-hydroxy-4-isoxazolyl)propionic acid [(S)-ATPA], is an (R,S)-2-amino-3-(5-methyl-3-hydroxy-4-isoxazolyl)propionic acid (AMPA) derivative in which the methyl group at
S E Lauri et al.
Neuropharmacology, 41(8), 907-915 (2001-12-19)
The development of GluR5-selective kainate receptor ligands is helping to elucidate the functions of kainate receptors in the CNS. Here we have further characterised the actions of a GluR5 selective agonist, ATPA, and a GluR5 selective antagonist, LY382884, in the
Jon Valgeirsson et al.
Journal of medicinal chemistry, 46(26), 5834-5843 (2003-12-12)
A series of 2-arylureidobenzoic acids (AUBAs) was prepared by a short and effective synthesis, and the pharmacological activity at glutamate receptors was evaluated in vitro and in vivo. The compounds showed noncompetitive antagonistic activity at the kainate receptor subtype GluR5.
Marie-Louise Lunn et al.
Journal of medicinal chemistry, 46(5), 872-875 (2003-02-21)
Two X-ray structures of the GluR2 ligand-binding core in complex with (S)-2-amino-3-(5-tert-butyl-3-hydroxy-4-isoxazolyl)propionic acid ((S)-ATPA) have been determined with and without Zn(2+) ions. (S)-ATPA induces a domain closure of ca. 21 degrees compared to the apo form. The tert-butyl moiety of
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