assay
≥75% (HPLC)
form
powder
color
faintly beige
solubility
H2O: 10 mg/mL
antibiotic activity spectrum
Gram-positive bacteria
mode of action
cell wall synthesis | interferes
shipped in
dry ice
storage temp.
−20°C
Application
A40926是一种抗生素，它是替考拉宁的类似物以及达巴瓦那的前体。 它是从野望菌属而分离得到的相关糖肽的混合物。 A40926可用于研究糖肽耐受的机制、抗生素产生的激活并用于药代动力学研究。
Biochem/physiol Actions
A40926可对革兰氏阳性细菌有效，并被发现可对淋病奈瑟菌具有高度杀菌作用。其作用机理是基于对细菌细胞壁的形成进行抑制。 A40926是四个主要因子的复合物。 这些因子都含有一个脂肪酸作为与肽主链相连的糖脂的一部分。
A40926可对革兰氏阳性细菌有效，并被发现对淋病奈瑟菌具有高度杀菌作用。其作用机理是对细菌细胞壁形成进行抑制。
Other Notes
A40926是一种抗生素，它是替考拉宁的类似物以及达巴瓦那的前体。 它是从野望菌属而分离得到的相关糖肽的混合物。
保存于密闭容器内，置于干燥通风处。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
涉药品监管产品
此项目有
A Bernareggi et al.
Antimicrobial agents and chemotherapy, 32(2), 246-249 (1988-02-01)
A40926 is a new glycopeptide antibiotic with unique activity against Neisseria gonorrhoeae and high and prolonged levels in mouse blood (B. P. Goldstein, E. Selva, L. Gastaldo, M. Berti, R. Pallanza, F. Ripamonti, P. Ferrari, M. Denaro, V. Arioli, and
B P Goldstein et al.
Antimicrobial agents and chemotherapy, 31(12), 1961-1966 (1987-12-01)
In the course of a search for glycopeptide antibiotics having novel biological properties, we isolated A40926. Produced by an actinomycete of the genus Actinomadura, A40926 is a complex of four main factors which contain a fatty acid as part of
Adelfia Talà et al.
Journal of bacteriology, 191(3), 805-814 (2008-12-03)
There is accumulating evidence that the ability of actinomycetes to produce antibiotics and other bioactive secondary metabolites has been underestimated due to the presence of cryptic gene clusters. The activation of dormant genes is therefore one of the most important
Giorgia Letizia Marcone et al.
Antimicrobial agents and chemotherapy, 54(6), 2465-2472 (2010-03-24)
In glycopeptide-resistant enterococci and staphylococci, high-level resistance is achieved by replacing the C-terminal d-alanyl-d-alanine of lipid II with d-alanyl-d-lactate, thus reducing glycopeptide affinity for cell wall targets. Reorganization of the cell wall in these organisms is directed by the vanHAX
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