A3546
Ala-Leu-Ala-Leu
≥97% (HPLC)
方案
≥97% (HPLC)
储存温度
−20°C
SMILES字符串
CC(C)CC(NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(C)N)C(O)=O
InChI
1S/C18H34N4O5/c1-9(2)7-13(21-15(23)11(5)19)17(25)20-12(6)16(24)22-14(18(26)27)8-10(3)4/h9-14H,7-8,19H2,1-6H3,(H,20,25)(H,21,23)(H,22,24)(H,26,27)
InChI key
KQRHTCDQWJLLME-UHFFFAOYSA-N
Amino Acid Sequence
Ala-Leu-Ala-Leu
生化/生理作用
A peptidase labile sequence used to link drugs to proteins or lipophilic carriers.
Ala-Leu-Ala-Leu (ALAL), a peptidase labile (cathepsin B) prodrug linker, is used to link bioavailable drugs to protein carriers such as albumin.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Trouet, A., et al. et al.
Targeting of Drugs, 19-30 (1982)
Björn Schmid et al.
Bioconjugate chemistry, 18(3), 702-716 (2007-03-24)
We have recently validated a macromolecular prodrug strategy for improved cancer chemotherapy based on two features: (a) rapid and selective binding of thiol-reactive prodrugs to the cysteine-34 position of endogenous albumin and (b) acid-sensitive promoted or enzymatic release of the
M Studer et al.
Bioconjugate chemistry, 3(5), 420-423 (1992-09-01)
The synthesis of a protected bifunctional analog of ethylenediaminetetraacetic acid (EDTA) is described. The molecule contains an aminobenzyl moiety that allows the easy attachment of the chelating agent to a wide variety of groups. Examples of reaction with the C-termini
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持