A3601
Anti-ADAM-19, N-Terminal antibody produced in rabbit
~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution
别名:
Anti-A Disintegrin And Metalloproteinase-19, Anti-Meltrin-β
产品名称
Anti-ADAM-19, N-Terminal antibody produced in rabbit, ~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous glycerol solution
species reactivity
human
concentration
~1 mg/mL
technique(s)
western blot: 1:1,000
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... ADAM19(8728)
Application
Rabbit anti-ADAM-19, N-Terminal antibody can be used for western blot assays at a dilution of 1:1,000. It can also be used for chemiluminescent immunoassays at 1:5,000.
General description
ADAM19 or Meltrin-beta belongs to the ADAM (a disintegrin and metalloprotease-like domain) family. ADAM19 is found in muscle, bone, muscle, lung, heart, brain, kidney, and several other cells. This protein shares homology with the fertilins (ADAMs 1 and 2). Studies have reported that ADAM19 is involved in myoblast fusion, similar to sperm-egg fusion aided by ADAMs 1 and 2. Furthermore, ADAM19 has been implicated in osteoblast and dendritic cell differentiation, as well as in the intracellular processing of neuregulin.
Rabbit anti-ADAM-19, N-Terminal antibody localizes human ADAM19. By immunoblotting against the reduced protein, the antibody recognizes bands at 60kDa and 50kDa from cell lysates.
Rabbit anti-ADAM-19, N-Terminal antibody localizes human ADAM19. By immunoblotting against the reduced protein, the antibody recognizes bands at 60kDa and 50kDa from cell lysates.
Immunogen
synthetic peptide corresponding to the N-terminal of furin-activated human ADAM-19.
Physical form
Solution in 0.01 M phosphate buffered saline containing 50% glycerol and 0.05% sodium azide.
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K Kurohara et al.
Biochemical and biophysical research communications, 270(2), 522-527 (2001-02-07)
Meltrin beta (ADAM19) is a member of the metalloprotease-disintegrin family. We report here chromosomal mapping of the mouse and rat meltrin beta genes and cloning and analysis of the mouse upstream regulatory regions. The meltrin beta transcript shows a spatially
J Fritsche et al.
Blood, 96(2), 732-739 (2000-07-11)
The 1alpha,25-dihydroxyvitamin D(3) (1,25- [OH](2)VD(3)) modulates the differentiation of monocytic cell lines and monocytes (MOs) in vitro. Up to now several target genes of 1,25(OH)(2)VD(3) have been described in monocytic cell lines; however, little is known about target genes in
K Shirakabe et al.
The Journal of biological chemistry, 276(12), 9352-9358 (2000-12-26)
Meltrin beta/ADAM19 is a member of ADAMs (a disintegrin and metalloproteases), which are a family of membrane-anchored glycoproteins that play important roles in fertilization, myoblast fusion, neurogenesis, and proteolytic processing of several membrane-anchored proteins. The expression pattern of meltrin beta
D Inoue et al.
The Journal of biological chemistry, 273(7), 4180-4187 (1998-03-28)
Here we report the cloning and initial biochemical characterization of the mouse metalloprotease/disintegrin/cysteine-rich (MDC) protein meltrin beta and the analysis of the mRNA expression of four MDC genes (meltrin alpha, meltrin beta, mdc9, and mdc15) in bone cells, including osteoclasts
P Wei et al.
Biochemical and biophysical research communications, 280(3), 744-755 (2001-02-13)
The adamalysins are involved in proteolysis, adhesion, fusion, and intracellular signaling. Human ADAM19/adamalysin-19 (A disintegrin and metalloproteinase 19) was identified from primary dendritic cell cDNA libraries. It has a signal sequence, a pro-domain with a "cysteine-switch" residue, a metalloproteinase domain
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