A4056
氨利酮
别名:
5-Amino-(3,4′-bipyridin)-6(1H)-one, Inamrinone
方案
≥98% (TLC)
质量水平
表单
powder
溶解性
1 M NaOH: 100 mg/mL
储存温度
2-8°C
SMILES字符串
NC1=CC(=CNC1=O)c2ccncc2
InChI
1S/C10H9N3O/c11-9-5-8(6-13-10(9)14)7-1-3-12-4-2-7/h1-6H,11H2,(H,13,14)
InChI key
RNLQIBCLLYYYFJ-UHFFFAOYSA-N
基因信息
human ... PDE3A(5139)
rat ... Pde3a(50678)
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生化/生理作用
Simple, non-glycoside cardiotonic agent, possibly via its phosphodiesterase III (PDE-III) inhibitory action.
Simple, non-glycoside cardiotonic agent, possibly via its phosphodiesterase III (PDE-III) inhibitory action. Independent of its cardiac effects, amrinone provides protection against ischemia-reperfusion injury in kidney, liver, and heart.
警示用语：
Danger
危险声明
预防措施声明
危险分类
Acute Tox. 3 Oral
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
新产品
此项目有
Greene Shepherd
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 63(19), 1828-1835 (2006-09-23)
The toxic effects and treatment of beta-adrenergic blocker and calcium-channel blocker (CCB) overdose are reviewed. Overdoses with cardiovascular drugs are associated with significant morbidity and mortality. Beta-blockers and CCBs represent the most important classes of cardiovascular drugs. In overdose, beta-blockers
Nuria Albet-Torres et al.
The Journal of biological chemistry, 284(34), 22926-22937 (2009-06-13)
Amrinone is a bipyridine compound with characteristic effects on the force-velocity relationship of fast skeletal muscle, including a reduction in the maximum shortening velocity and increased maximum isometric force. Here we performed experiments to elucidate the molecular mechanisms for these
Kiyokazu Yunomae et al.
Journal of applied toxicology : JAT, 27(1), 78-85 (2006-12-06)
It is presumed that phosphodiesterase (PDE) inhibitors have two mechanisms for inhibition of hERG currents in the acute applications to cells: direct channel block, and downregulation of human ether-a-go-go related gene (hERG) activities by PKA-dependent pathway mediated phosphorylation through their
Thiranat Tanwiphongtrakun et al.
Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists, 44(3), 183-185 (2006-10-14)
We came across a case who because of sustained hypotension with normal cardiac output was given amrinone which offered an initial excellent response but showed impotency later and its replacement by milrinone dramatically improved the hemodynamic status. The ensuing hypotension
Alousi, A.A., et al.
Federation Proceedings, 37, 3692-3692 (1978)
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