A4056
氨利酮
别名:
5-Amino-(3,4′-bipyridin)-6(1H)-one, Inamrinone
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关于此项目
经验公式（希尔记法）:
C10H9N3O
化学文摘社编号:
分子量:
187.20
UNSPSC Code:
12352202
PubChem Substance ID:
EC Number:
262-390-0
MDL number:
InChI key
RNLQIBCLLYYYFJ-UHFFFAOYSA-N
InChI
1S/C10H9N3O/c11-9-5-8(6-13-10(9)14)7-1-3-12-4-2-7/h1-6H,11H2,(H,13,14)
SMILES string
NC1=CC(=CNC1=O)c2ccncc2
assay
≥98% (TLC)
form
powder
solubility
1 M NaOH: 100 mg/mL
storage temp.
2-8°C
Quality Level
Gene Information
human ... PDE3A(5139)
rat ... Pde3a(50678)
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Biochem/physiol Actions
Simple, non-glycoside cardiotonic agent, possibly via its phosphodiesterase III (PDE-III) inhibitory action.
Simple, non-glycoside cardiotonic agent, possibly via its phosphodiesterase III (PDE-III) inhibitory action. Independent of its cardiac effects, amrinone provides protection against ischemia-reperfusion injury in kidney, liver, and heart.
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
新产品
此项目有
M P Rechtman et al.
European journal of pharmacology, 402(3), 255-262 (2000-08-26)
We investigated the effects of amrinone on ischaemia-induced changes in myocardial function in isolated rat hearts. Isolated hearts from male Sprague-Dawley rats (150-275 g) were perfused with physiological salt solution at a constant flow rate. The effects of amrinone (30
Kazuo Komamura et al.
Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research, 11 Suppl 1, S39-S42 (2008-04-17)
Phosphodiesterase (PDE) III inhibitor therapy is effective for treatment of acute decompensated heart failure (ADHF). Nevertheless, this drug is expensive than conventional inotropic agent dobutamine. We compared total medication costs of the patients treated with PDE III inhibitor amrinone therapy
Seyed Mohammad-Taghi Mansouri et al.
Iranian biomedical journal, 12(2), 77-84 (2008-05-29)
Selective phosphodiesterase (PDE3) inhibitors improve cardiac contractility and may use in congestive heart failure. However, their proarrhythmic potential is the most important side effect. In this research, we evaluated the potential cardiotonic activity of six new synthesized selective PDE3 inhibitors
R Karabulut et al.
Urological research, 30(3), 164-168 (2002-07-12)
Renal ischemia/reperfusion injury could arise as a consequence of clinical conditions such as renal transplantation, shock, cardiac arrest, hemorrhage and renal artery surgery. In this experimental study, we aimed to determine the preventive effects of amrinone on bilateral renal ischemia/reperfusion
Yoshihiro Ko et al.
Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 15(5), 311-317 (2009-11-11)
Phosphodiesterase (PDE) III inhibitors have been reported in various cellular protective activities via the cyclic adenosine monophosphate (cAMP) pathway. We investigated the effects of amrinone on ischemia/reperfusion injury and intracellular calcium (Ca2+) handling if utilized as a component of terminal
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