A4056
氨利酮
别名:
5-Amino-(3,4′-bipyridin)-6(1H)-one, Inamrinone
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关于此项目
经验公式（希尔记法）:
C10H9N3O
化学文摘社编号:
分子量:
187.20
UNSPSC Code:
12352202
PubChem Substance ID:
EC Number:
262-390-0
MDL number:
InChI key
RNLQIBCLLYYYFJ-UHFFFAOYSA-N
InChI
1S/C10H9N3O/c11-9-5-8(6-13-10(9)14)7-1-3-12-4-2-7/h1-6H,11H2,(H,13,14)
SMILES string
NC1=CC(=CNC1=O)c2ccncc2
assay
≥98% (TLC)
form
powder
solubility
1 M NaOH: 100 mg/mL
storage temp.
2-8°C
Quality Level
Gene Information
human ... PDE3A(5139)
rat ... Pde3a(50678)
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Biochem/physiol Actions
Simple, non-glycoside cardiotonic agent, possibly via its phosphodiesterase III (PDE-III) inhibitory action.
Simple, non-glycoside cardiotonic agent, possibly via its phosphodiesterase III (PDE-III) inhibitory action. Independent of its cardiac effects, amrinone provides protection against ischemia-reperfusion injury in kidney, liver, and heart.
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
新产品
此项目有
Thiranat Tanwiphongtrakun et al.
Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists, 44(3), 183-185 (2006-10-14)
We came across a case who because of sustained hypotension with normal cardiac output was given amrinone which offered an initial excellent response but showed impotency later and its replacement by milrinone dramatically improved the hemodynamic status. The ensuing hypotension
Kiyokazu Yunomae et al.
Journal of applied toxicology : JAT, 27(1), 78-85 (2006-12-06)
It is presumed that phosphodiesterase (PDE) inhibitors have two mechanisms for inhibition of hERG currents in the acute applications to cells: direct channel block, and downregulation of human ether-a-go-go related gene (hERG) activities by PKA-dependent pathway mediated phosphorylation through their
Nuria Albet-Torres et al.
The Journal of biological chemistry, 284(34), 22926-22937 (2009-06-13)
Amrinone is a bipyridine compound with characteristic effects on the force-velocity relationship of fast skeletal muscle, including a reduction in the maximum shortening velocity and increased maximum isometric force. Here we performed experiments to elucidate the molecular mechanisms for these
Greene Shepherd
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 63(19), 1828-1835 (2006-09-23)
The toxic effects and treatment of beta-adrenergic blocker and calcium-channel blocker (CCB) overdose are reviewed. Overdoses with cardiovascular drugs are associated with significant morbidity and mortality. Beta-blockers and CCBs represent the most important classes of cardiovascular drugs. In overdose, beta-blockers
Alousi, A.A., et al.
Federation Proceedings, 37, 3692-3692 (1978)
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