A4101
Anti-ADAM-19, Cytoplasmic Domain antibody produced in rabbit
~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution
别名:
Anti-A Disintegrin And Metalloproteinase-19, Anti-Meltrin-β
生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous glycerol solution
种属反应性
human
浓度
~1 mg/mL
技术
western blot (chemiluminescent): 1:5,000
western blot: 1:1,000
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... ADAM19(8728)
一般描述
ADAM19 or Meltrin-beta belongs to the ADAM (a disintegrin and metalloprotease-like domain) family. ADAM19 is found in muscle, bone, muscle, lung, heart, brain, kidney, and several other cells. This protein shares homology with the fertilins (ADAMs 1 and 2). Studies have reported that ADAM19 is involved in myoblast fusion, similar to sperm-egg fusion aided by ADAMs 1 and 2. Furthermore, ADAM19 has been implicated in osteoblast and dendritic cell differentiation, as well as in the intracellular processing of neuregulin.
Anti-ADAM-19, cytoplasmic domain, localizes human ADAM19. By immunoblotting against the reduced protein, the antibody recognizes bands at 95kDa, 120kDa, and breakdown products at 36kDa and 20kDa from cell lysates. A 50kDa band may be seen in some lysates, which may represent a cleaved form of ADAM19.
Anti-ADAM-19, cytoplasmic domain, localizes human ADAM19. By immunoblotting against the reduced protein, the antibody recognizes bands at 95kDa, 120kDa, and breakdown products at 36kDa and 20kDa from cell lysates. A 50kDa band may be seen in some lysates, which may represent a cleaved form of ADAM19.
免疫原
synthetic peptide corresponding to the cytoplasmic domain of human ADAM-19.
应用
Rabbit anti-ADAM-19, cytoplasmic domain antibody can be used for western blot assays at a dilution of 1:1,000. For chemiluminescent substrates, a starting dilution of 1:5,000 of the antibody is recommended.
外形
Solution in 0.01 M phosphate buffered saline containing 50% glycerol and 0.05% sodium azide.
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P Wei et al.
Biochemical and biophysical research communications, 280(3), 744-755 (2001-02-13)
The adamalysins are involved in proteolysis, adhesion, fusion, and intracellular signaling. Human ADAM19/adamalysin-19 (A disintegrin and metalloproteinase 19) was identified from primary dendritic cell cDNA libraries. It has a signal sequence, a pro-domain with a "cysteine-switch" residue, a metalloproteinase domain
K Shirakabe et al.
The Journal of biological chemistry, 276(12), 9352-9358 (2000-12-26)
Meltrin beta/ADAM19 is a member of ADAMs (a disintegrin and metalloproteases), which are a family of membrane-anchored glycoproteins that play important roles in fertilization, myoblast fusion, neurogenesis, and proteolytic processing of several membrane-anchored proteins. The expression pattern of meltrin beta
J Fritsche et al.
Blood, 96(2), 732-739 (2000-07-11)
The 1alpha,25-dihydroxyvitamin D(3) (1,25- [OH](2)VD(3)) modulates the differentiation of monocytic cell lines and monocytes (MOs) in vitro. Up to now several target genes of 1,25(OH)(2)VD(3) have been described in monocytic cell lines; however, little is known about target genes in
D Inoue et al.
The Journal of biological chemistry, 273(7), 4180-4187 (1998-03-28)
Here we report the cloning and initial biochemical characterization of the mouse metalloprotease/disintegrin/cysteine-rich (MDC) protein meltrin beta and the analysis of the mRNA expression of four MDC genes (meltrin alpha, meltrin beta, mdc9, and mdc15) in bone cells, including osteoclasts
K Kurohara et al.
Biochemical and biophysical research communications, 270(2), 522-527 (2001-02-07)
Meltrin beta (ADAM19) is a member of the metalloprotease-disintegrin family. We report here chromosomal mapping of the mouse and rat meltrin beta genes and cloning and analysis of the mouse upstream regulatory regions. The meltrin beta transcript shows a spatially
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