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Merck
CN

A4142

偶氮丝氨酸

≥98% (TLC)

别名:

O-重氮乙酰基-L-丝氨酸

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关于此项目

经验公式(希尔记法):
C5H7N3O4
化学文摘社编号:
分子量:
173.13
UNSPSC Code:
12352209
NACRES:
NA.26
PubChem Substance ID:
EC Number:
204-061-6
Beilstein/REAXYS Number:
1726602
MDL number:
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Quality Segment

assay

≥98% (TLC)

form

powder

color

off-white to yellow-green

antibiotic activity spectrum

fungi

mode of action

enzyme | inhibits

storage temp.

−20°C

SMILES string

N[C@@H](COC(=O)C=[N+]=[N-])C(O)=O

InChI

1S/C5H7N3O4/c6-3(5(10)11)2-12-4(9)1-8-7/h1,3H,2,6H2,(H,10,11)/t3-/m0/s1

InChI key

MZZGOOYMKKIOOX-VKHMYHEASA-N

General description

Chemical structure: amino acid derivatives

Application

Used in cell culture for the selection of HGPRT revertants.

Biochem/physiol Actions

Azaserine is an antibiotic and antifungal; it may also act as a tumor inducer. It is a structural analog of glutamine and competes with glutamine in binding to enzymes involved in purine biosynthesis. Azaserine inhibits purine biosynthesis by covalently reacting with cysteine residues in the enzyme active sites, such as in formylglycinamide ribonucleotide amidotransferase and PRPP amidotransferase. Azaserine can induce DNA damage via the formation of carboxymethylated bases and O6-methylguanine. Secretion of exo-1,3-β-glucanase and germ-tube formation of Candida albicans were inhibited by azaserine.


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pictograms

Skull and crossbonesHealth hazard

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 3 Oral - Carc. 2

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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相关内容

Product Information Sheet






全球贸易项目编号

货号GTIN
A4142-10MG04061832414829
A4142-5MG04061832414843
A4142-250MG04061832414836
A4142-50MG04061833368534