A4336
4-Aminobenzoyl-Gly-Pro-D-Leu-D-Ala hydroxamic acid
≥95% (HPLC)
别名:
FN-439
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关于此项目
经验公式（希尔记法）:
C23H34N6O6
化学文摘社编号:
分子量:
490.55
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥95% (HPLC)
Form:
powder
assay
≥95% (HPLC)
form
powder
solubility
H2O: 1 mg/mL
storage temp.
−20°C
SMILES string
CC(C)C[C@@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)c2ccc(N)cc2)C(=O)N[C@H](C)C(=O)NO
InChI
1S/C23H34N6O6/c1-13(2)11-17(22(33)26-14(3)20(31)28-35)27-23(34)18-5-4-10-29(18)19(30)12-25-21(32)15-6-8-16(24)9-7-15/h6-9,13-14,17-18,35H,4-5,10-12,24H2,1-3H3,(H,25,32)(H,26,33)(H,27,34)(H,28,31)/t14-,17-,18+/m1/s1
InChI key
WWHUHFFMOPIVKB-OLMNPRSZSA-N
Gene Information
human ... COL1A1(1277), MMP1 (includes EG:4312)
mouse ... COL1A1(12842), MMP1 (includes EG:4312)
rat ... COL1A1(29393), MMP1 (includes EG:4312)
Biochem/physiol Actions
Collagenase Inhibitor
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Lina María Preciado et al.
Toxins, 12(1) (2019-12-22)
Snake bite envenoming is a public health problem that was recently included in the list of neglected tropical diseases of the World Health Organization. In the search of new therapies for the treatment of local tissue damage induced by snake
K Kigasawa et al.
Japanese journal of ophthalmology, 39(1), 35-42 (1995-01-01)
The inhibitory activity of a new peptidyl collagenase inhibitor, FN-439 or tetrapeptidyl hydroxamic acid (H2N-C6H4-CO-Gly-L-Pro-D-Leu-D-Ala-NHOH), was determined against vertebrate collagenases derived from human fibroblast, human polymorphonuclear leukocyte (PMN) and tadpole skin. In addition, the effect of FN-439 in inhibiting corneal
S Odake et al.
Chemical & pharmaceutical bulletin, 39(6), 1489-1494 (1991-06-01)
To develop a potent and specific collagenase inhibitor, a series of tetrapeptidyl hydroxamic acids were synthesized, based on the previous findings with tripeptidyl derivatives (Chem. Pharm. Bull., 38, 1007-1011, 1990). Among the series of tetrapeptidyl derivatives synthesized, R-Gly-Pro-Leu-Ala-NHOH and R-Gly-Pro-D-Leu-D-Ala-NHOH
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| A4336-5MG | 04061833258156 |