Anti-ADAM-17, Cytoplasmic Domain antibody produced in rabbit

ADAM-17 or tumor necrosis factor converting enzyme (TACE) is known to regulate several cellular functions such as cell growth and movement. It has a varied array of substrates that include adhesion molecules, growth factors and their receptors, as well as many cytokines. Thus, ADAM-17 abnormalities have been associated with various disorders such as renal fibrosis, Alzheimer′s disease, rheumatoid arthritis, cancer, diabetes and cardiac disorders.
Rabbit anti-ADAM-17, cytoplasmic domain antibody recognizes human, porcine, and rat ADAM17. It does not react with other ADAMs. By immunoblotting against the reduced protein, the antibody recognizes a band of 110kDa from conditioned media or cell lysates.

synthetic peptide corresponding to the cytoplasmic domain of full-length human ADAM-17.

Rabbit anti-ADAM-17, cytoplasmic domain antibody can be used for western blot at a dilution of 1:1,000.

Solution in 0.01 M phosphate buffered saline containing 50% glycerol and 0.05% sodium azide.

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