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Merck
CN

A4403

Sigma-Aldrich

L -抗坏血酸

powder, suitable for cell culture, γ-irradiated

别名:

维他命C, 抗坏血病因子, 维生素C

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关于此项目

经验公式（希尔记法）:
C6H8O6
化学文摘社编号:
50-81-7
分子量:
176.12
Beilstein:
84272
EC 号:
200-066-2
MDL编号:
MFCD00064328
UNSPSC代码:
12352207
PubChem化学物质编号:
24890857
NACRES:
NA.75

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生物来源

synthetic (organic)

质量水平

200

无菌性

γ-irradiated

表单

powder

分子量

Mw 176.12 g/mol

技术

cell culture | insect: suitable
cell culture | mammalian: suitable
cell culture | plant: suitable

颜色

white to off-white

pH值（酸碱度）

1.0-2.5 (25 °C, 176 g/L in water)

mp

190-194 °C (dec.)

溶解性

H2O: 10 mg/mL

SMILES字符串

OC([C@]([C@@H](O)CO)([H])O1)=C(O)C1=O

InChI

1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1

InChI key

CIWBSHSKHKDKBQ-JLAZNSOCSA-N

基因信息

human ... SLC23A2(9962)

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相关类别

一般描述

L-抗坏血酸是一种不饱和γ-内酯环，含有与羰基相连的烯二醇构型(-COH =COH)。

应用

用于细胞培养，作为抗氧化剂和再生生育酚。
L-抗坏血酸已应用于：
  • 用于细胞生长的成骨补充剂
  • 作为分化介质的一个组成部分
  • 在WS-MSCs(沃纳综合征-间充质干细胞)中研究抗坏血酸对衰老缺陷的修复作用

生化/生理作用

L-抗坏血酸主要具有抗氧化性能。它保护植物免受氧化应激，保护哺乳动物免受与氧化应激相关的疾病。L-抗坏血酸主要对羟基自由基、超氧化物和单线态氧起保护作用。此外，它还还原膜连接的抗氧化剂α-生育酚(氧化形式)。L-抗坏血酸增强内皮依赖性血管舒张在各种疾病，包括糖尿病，冠状动脉疾病，高血压和慢性心力衰竭。

其他说明

2024年CiteAb奖——成功的帕金森研究供应商(2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research)

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000285277
0000285277
0000411196
0000411196
0000346373

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R Heller et al.
The Journal of biological chemistry, 274(12), 8254-8260 (1999-03-13)
Ascorbic acid has been shown to enhance impaired endothelium-dependent vasodilation in patients with atherosclerosis by a mechanism that is thought to involve protection of nitric oxide (NO) from inactivation by free oxygen radicals. The present study in human endothelial cells
P L Conklin et al.
Plant physiology, 115(3), 1277-1285 (1997-12-09)
The biosynthesis of L-ascorbic acid (vitamin C) is not well understood in plants. The ozone-sensitive Arabidopsis thaliana mutant vitamin c-1 (vtc1; formerly known as soz1) is deficient in ascorbic acid, accumulating approximately 30% of wild-type levels. This deficiency could result
Plant L-ascorbic acid: chemistry, function, metabolism, bioavailability and effects of processing.
Davey MW
Journal of the Science of Food and Agriculture, 80, 825-860 (2000)
Xi Wang et al.
Archives of oral biology, 57(9), 1231-1240 (2012-03-30)
This study focused on the characterization of stem cells from human exfoliated deciduous teeth (SHED) in comparison with dental pulp stem cells (DPSCs) to certify SHED as a key element in tissue engineering. In the present study, SHED and DPSCs
Ying Li et al.
Protein & cell, 7(7), 478-488 (2016-06-09)
Werner syndrome (WS) is a premature aging disorder that mainly affects tissues derived from mesoderm. We have recently developed a novel human WS model using WRN-deficient human mesenchymal stem cells (MSCs). This model recapitulates many phenotypic features of WS. Based
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