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A4730

Amthamine dihydrobromide

Name: Amthamine dihydrobromide
Brand: SIGMA

≥98% (HPLC), solid

别名:

2-Amino-4-methyl-5-thiazoleethanamine dihydrobromide

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关于此项目

经验公式（希尔记法）:

C₆H₁₁N₃S · 2HBr

化学文摘社编号:

142457-00-9

分子量:

319.06

NACRES:

NA.77

PubChem Substance ID:

24890905

UNSPSC Code:

12352200

MDL number:

MFCD00673891

Assay:

≥98% (HPLC)

Form:

solid

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assay

≥98% (HPLC)

form

solid

color

off-white

solubility

H₂O: 27 mg/mL

storage temp.

2-8°C

SMILES string

Br[H].Br[H].Cc1nc(N)sc1CCN

InChI

1S/C6H11N3S.2BrH/c1-4-5(2-3-7)10-6(8)9-4;;/h2-3,7H2,1H3,(H2,8,9);2*1H

InChI key

XFXNNOPUDSFVJE-UHFFFAOYSA-N

Application

Amthamine dihydrobromide is a histamine H₂ receptor agonist. Amthamine dihydrobromide has been used to study the effect of mast cells on T regulatory cell function.

Biochem/physiol Actions

Amthamine dihydrobromide is a H₂ histamine receptor agonist. Amthamine dihydrobromide, similar to histamine, inhibits H₂ receptor-mediated eosinophil peroxidase (EPO) release with IC₅₀ = 0.4 μM; a weak antagonist at H₃ and shows no activity at H₁receptors.

H₂ histamine receptor agonist.

存储类别

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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The new potent and selective histamine H2 receptor agonist amthamine as a tool to study gastric secretion.

G Coruzzi et al.

Naunyn-Schmiedeberg's archives of pharmacology, 348(1), 77-81 (1993-07-01)

The new histamine H2 receptor agonist amthamine, [2-amino-5-(2-aminoethyl)-4-methylthiazole], was tested for its activity on gastric acid secretion in different in vivo and in vitro experimental models. Amthamine induced a dose-related increase in acid secretion both in conscious cats with a

Histamine Induces Microglia Activation and the Release of Proinflammatory Mediators in Rat Brain Via H1R or H4R.

Wei Zhang et al.

Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 15(2), 280-291 (2019-12-22)

Histamine is a major peripheral inflammatory mediator and a neurotransmitter in the central nervous system. We have reported that histamine induces microglia activation and releases proinflammatory factors in primary cultured microglia. Whether histamine has similar effects in vivo is unknown.

Cardiac effects of amthamine: a new histamine H2-receptor agonist.

G Coruzzi et al.

European journal of clinical investigation, 25 Suppl 1, 27-28 (1995-03-01)

Histamine 2/3 receptor agonists alleviate perioperative neurocognitive disorders by inhibiting microglia activation through the PI3K/AKT/FoxO1 pathway in aged rats.

Yi-Nan Chen et al.

Journal of neuroinflammation, 17(1), 217-217 (2020-07-24)

Microglia, the principal sentinel immune cells of the central nervous system (CNS), play an extensively vital role in neuroinflammation and perioperative neurocognitive disorders (PND). Histamine, a potent mediator of inflammation, can both promote and prevent microglia-related neuroinflammation by activating different

Histamine H2 receptor trafficking: role of arrestin, dynamin, and clathrin in histamine H2 receptor internalization.

Natalia Fernandez et al.

Molecular pharmacology, 74(4), 1109-1118 (2008-07-12)

Agonist-induced internalization of G protein-coupled receptors (GPCRs) has been implicated in receptor desensitization, resensitization, and down-regulation. In the present study, we sought to establish whether the histamine H2 receptor (H2r) agonist amthamine, besides promoting receptor desensitization, induced H2r internalization. We

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全球贸易项目编号

货号	GTIN
A4730-10MG	04061832079158
A4730-50MG	04061832079165

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