A4887
天门冬酰胺酶 来源于大肠杆菌
Grade V, buffered aqueous glycerol solution, ≥80 units/mg protein
别名:
L -天冬酰胺酰胺水解酶
type
Grade V
form
buffered aqueous glycerol solution
specific activity
≥80 units/mg protein
storage temp.
2-8°C
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Physical form
Solution in 50% glycerol, pH 6.5
Analysis Note
Protein determined by biuret.
Other Notes
One unit will liberate 1.0 μmole of ammonia from L-asparagine per min at pH 8.6 at 37 °C.
法规信息
新产品
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Lynda M Vrooman et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(9), 1202-1210 (2013-01-30)
We assessed the toxicity and efficacy of dexamethasone and a novel dosing method of Escherichia coli L-asparaginase (EC-Asnase) in children and adolescents with newly diagnosed acute lymphoblastic leukemia (ALL). Patients achieving complete remission (CR) on Dana-Farber Cancer Institute ALL Consortium
Marieta Anton-Harisi et al.
Journal of pediatric hematology/oncology, 34(8), e337-e340 (2012-09-18)
We describe 2 patients, a 4-month-old male and a 17-month-old female, with de novo acute megakaryoblastic leukemia with increased number of hematogones at diagnosis. Both children were admitted in the hospital with thrombocytopenia. The bone marrow smears in the first
Jassada Buaboonnam et al.
Pediatric blood & cancer, 60(7), 1161-1164 (2013-01-22)
The efficacy of combination chemotherapy with methotrexate (MTX) and asparaginase is not well known in relapsed and refractory acute leukemia after contemporary therapy. A retrospective study of pediatric patients with relapsed or refractory acute myeloid leukemia (AML) who received MTX
E Truelove et al.
Leukemia, 27(3), 553-559 (2012-10-27)
The dramatic improvements seen in the outcome of paediatric patients with acute lymphoblastic leukaemia (ALL) have led to increasing incorporation of L-asparaginase (L-Asp) in adult treatment protocols. However, its use is associated with a disruption in the physiological balance between
Carmelo Rizzari et al.
Current opinion in oncology, 25 Suppl 1, S1-S9 (2013-02-13)
Asparaginases are important agents used in the treatment of children with acute lymphoblastic leukemia (ALL). Three types of asparaginase are currently available: two are derived from Escherichia coli [native asparaginase and pegylated asparaginase (PEG-asparaginase)] and one from Erwinia chrysanthemi (crisantaspase).
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