方案
>98% (HPLC)
表单
powder
颜色
white
溶解性
DMSO: soluble ~20 mg/mL
运输
wet ice
储存温度
−20°C
SMILES字符串
N[C@@H](COC(c1cccc(F)c1)c2ccccc2OCc3ccccc3)C(O)=O
InChI
1S/C23H22FNO4/c24-18-10-6-9-17(13-18)22(29-15-20(25)23(26)27)19-11-4-5-12-21(19)28-14-16-7-2-1-3-8-16/h1-13,20,22H,14-15,25H2,(H,26,27)/t20-,22?/m0/s1
InChI key
ADUSZEGHFWRTQS-AIBWNMTMSA-N
应用
ALX-1393 is a GlyT-2 glycine transporter inhibitor and GlyT2 may be a novel therapeutic target for the treatment of overactive bladder and/or bladder hypersensitive disorders such as bladder pain syndrome/interstitial cystitis.
生化/生理作用
GlyT-2 glycine transporter inhibitor.
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Glycine Transporter Type 2 (GlyT2) Inhibitor Ameliorates Bladder Overactivity and Nociceptive Behavior in Rats
Yoshikawa, S., et al.
European Urology, doi: 10-doi: 10 (2012)
Hyo-Jin Jeong et al.
British journal of pharmacology, 161(4), 925-935 (2010-09-24)
The arachidonyl-amino acid N-arachidonyl-glycine (NAGly) is an endogenous lipid, generated within the spinal cord and producing spinally mediated analgesia via non-cannabinoid mechanisms. In this study we examined the actions of NAGly on neurons within the superficial dorsal horn, a key
Thomas M Ackermann et al.
ChemMedChem, 16(1), 199-215 (2020-08-01)
This study describes the first binding assay for glycine transporter 2 (GlyT2) following the concept of MS Binding Assays. The selective GlyT2 inhibitor Org25543 was employed as a reporter ligand and it was quantified with a highly sensitive and rapid
Birgit Nimmervoll et al.
Neuroreport, 22(10), 509-513 (2011-06-15)
To investigate whether glycine receptors influence radial migration in the neocortex, we analyzed the effect of glycine and the glycinergic antagonist strychnine, on the distribution of 5-bromo-2'deoxyuridine-labeled neurons in organotypic slice cultures from embryonic mice cortices. Application of glycine impeded
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