A5656
(±)-毒藜碱
≥90% (TLC), liquid
别名:
3-(2-哌啶基)吡啶, 新烟碱
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关于此项目
经验公式（希尔记法）:
C10H14N2
化学文摘社编号:
分子量:
162.23
UNSPSC Code:
12352100
PubChem Substance ID:
MDL number:
InChI
1S/C10H14N2/c1-2-7-12-10(5-1)9-4-3-6-11-8-9/h3-4,6,8,10,12H,1-2,5,7H2
SMILES string
C1CCC(NC1)c2cccnc2
InChI key
MTXSIJUGVMTTMU-UHFFFAOYSA-N
assay
≥90% (TLC)
form
liquid
optical activity
[α]25/D 0°, c = 1 in H2O(lit.)
color
colorless to yellow
transition temp
freezing point 9 °C
solubility
H2O: 10 mg/mL, ethanol: 50 mg/mL
density
1.05 g/mL at 25 °C (lit.)
application(s)
agriculture
environmental
Gene Information
mouse ... Chrna7(11441), Chrnb1(11443)
Biochem/physiol Actions
烟叶生物碱；烟碱型乙酰胆碱受体的强效激动剂。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
199.4 °F - closed cup
flash_point_c
93 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
新产品
此项目有
P M Gocze et al.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 13(4), 266-272 (1999-10-26)
To reveal the well known effect of smoking on the incidence of early abortion, the possible effects of cigarette alkaloids on progesterone and estradiol synthesis were investigated. A suspected cause for early spontaneous abortion is corpus luteum insufficiency. The present
M J Parker et al.
Molecular pharmacology, 54(6), 1132-1139 (1998-12-18)
We used equilibrium binding analysis to characterize the agonist binding properties of six different rat neuronal nicotinic receptor subunit combinations expressed in Xenopus laevis oocytes. The alpha4beta2 receptor bound [3H]cytisine with a Kdapp of 0.74 +/- 0. 14 nM. The
W R Kem et al.
The Journal of pharmacology and experimental therapeutics, 283(3), 979-992 (1998-02-12)
We assessed the pharmacological activity of anabaseine, a toxin found in certain animal venoms, relative to nicotine and anabasine on a variety of vertebrate nicotinic receptors, using cultured cells, the Xenopus oocyte expression system, contractility assays with skeletal and smooth
Y Lu et al.
The Journal of pharmacology and experimental therapeutics, 291(3), 1127-1134 (1999-11-24)
Several neurochemical and electrophysiological studies have shown that neuronal nicotinic receptors are desensitized by pretreatment with lower agonist concentrations than are required to activate the receptors, but the extent of desensitization and agonist concentration required to produce desensitization vary depending
J L Castorena et al.
Journal of toxicology. Clinical toxicology, 25(5), 429-435 (1987-01-01)
A young adult male was found dead in a field. No cause of death was apparent at autopsy, and the only positive toxicological finding was the presence of a nicotine-like alkaloid isolated from the liver. Anabasine, the major, highly toxic
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