A5763
腺苷 3′,5′-二磷酸 二钠盐
≥96%, synthetic (inorganic), powder
别名:
3′-磷酸腺苷-5′-磷酸盐, 前列腺酸性磷酸酶
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关于此项目
经验公式（希尔记法）:
C10H13N5Na2O10P2
化学文摘社编号:
分子量:
471.16
UNSPSC Code:
41106305
eCl@ss:
32160414
PubChem Substance ID:
NACRES:
NA.51
MDL number:
产品名称
腺苷 3′,5′-二磷酸 二钠盐, ≥96%
SMILES string
[Na].Nc1ncnc2n(cnc12)C3OC(COP(O)(O)=O)C(OP(O)(O)=O)C3O
InChI key
ISROZYFZEAVMSP-UHFFFAOYSA-N
InChI
1S/C10H15N5O10P2.Na.H/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19;;/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22);;
biological source
synthetic (inorganic)
assay
≥96%
form
powder
solubility
water: 25 mg/mL, clear, colorless to very faintly yellow
storage temp.
−20°C
Quality Level
Application
腺苷3′,5′-二磷酸二钠盐用于：
- 在二维薄层色谱中，在纤维素高效薄层色谱（HPTLC）板上点样
- 在酶活性试验中，研究 HOS2 / FIERY1野生型
- hos2突变体和fiery1？2突变蛋白对3′-磷酸磷腺苷5′-磷酸（PAP）的活性
- 作为标准品，定量磷酸腺苷
Biochem/physiol Actions
3′-磷酸磷腺苷5′-磷酸（PAP）能阻断细胞核和胞质溶胶中核糖核酸外切酶（XRN）的活性。 它刺激气孔关闭，在脱落酸（ABA）信号传递过程中作为第二信使。能够阻断RNA分解代谢。因此，它可以作为生理调节剂，调控聚（ADP-核糖）聚合酶1（PARP1）活性。
腺苷 3′,5′-二磷酸 (PAP)可用于研究羟类固醇磺基转移酶 （如SULT1A1、SULT2A1） 的动力学和作用机理，其是产物抑制剂。
General description
3′-磷酸腺苷5′-磷酸（PAP），为3′-磷酸化的核苷酸，几乎存在于所有生物中，是硫和脂质代谢的副产物。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
Zhihao Yu et al.
Biochemistry, 47(48), 12777-12786 (2008-11-11)
Most assimilatory bacteria, fungi, and plants species reduce sulfate (in the activated form of APS or PAPS) to produce reduced sulfur. In yeast, PAPS reductase reduces PAPS to sulfite and PAP. Despite the difference in substrate specificity and catalytic cofactor
3?-phosphoadenosine 5?-phosphate accumulation delays the circadian system
Litthauer S, et al.
Plant Physiology, 176(4), 3120-3135 (2018)
Hayrettin Ozan Gulcan et al.
Archives of biochemistry and biophysics, 507(2), 232-240 (2010-12-29)
The cytosolic sulfotransferase hSULT2A1 is the major hydroxysteroid (alcohol) sulfotransferase in human liver, and it catalyzes the 3'-phosphoadenosine-5'-phosphosulfate (PAPS)-dependent sulfation of various endogenous hydroxysteroids as well as many xenobiotics that contain alcohol and phenol functional groups. The hSULT2A1 often displays
Bok-Rye Lee et al.
PloS one, 7(6), e39425-e39425 (2012-06-23)
The fou8 loss of function allele of adenosine bisphosphate phosphatase FIERY1 results in numerous phenotypes including the increased enzymatic oxygenation of fatty acids and increased jasmonate synthesis. Here we show that the mutation causes also profound alterations of sulfur metabolism.
Yungang Liu et al.
Chemico-biological interactions, 189(3), 153-160 (2010-12-07)
Hydroxylated metabolites of polychlorinated biphenyls (OHPCBs) interact with rat sulfotransferase 1A1 (rSULT1A1) as substrates and inhibitors. Previous studies have shown that there are complex and incompletely understood structure-activity relationships governing the interaction of rSULT1A1 with these molecules. Furthermore, modification of
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