A5763
腺苷 3′,5′-二磷酸 二钠盐
≥96%, synthetic (inorganic), powder
别名:
3′-磷酸腺苷-5′-磷酸盐, 前列腺酸性磷酸酶
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关于此项目
经验公式（希尔记法）:
C10H13N5Na2O10P2
化学文摘社编号:
分子量:
471.16
MDL编号:
UNSPSC代码:
41106305
eCl@ss:
32160414
PubChem化学物质编号:
NACRES:
NA.51
产品名称
腺苷 3′,5′-二磷酸 二钠盐, ≥96%
生物来源
synthetic (inorganic)
质量水平
方案
≥96%
表单
powder
溶解性
water: 25 mg/mL, clear, colorless to very faintly yellow
储存温度
−20°C
SMILES字符串
[Na].Nc1ncnc2n(cnc12)C3OC(COP(O)(O)=O)C(OP(O)(O)=O)C3O
InChI
1S/C10H15N5O10P2.Na.H/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19;;/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22);;
InChI key
ISROZYFZEAVMSP-UHFFFAOYSA-N
一般描述
3′-磷酸腺苷5′-磷酸（PAP），为3′-磷酸化的核苷酸，几乎存在于所有生物中，是硫和脂质代谢的副产物。
应用
腺苷3′,5′-二磷酸二钠盐用于：
- 在二维薄层色谱中，在纤维素高效薄层色谱（HPTLC）板上点样
- 在酶活性试验中，研究 HOS2 / FIERY1野生型
- hos2突变体和fiery1？2突变蛋白对3′-磷酸磷腺苷5′-磷酸（PAP）的活性
- 作为标准品，定量磷酸腺苷
生化/生理作用
3′-磷酸磷腺苷5′-磷酸（PAP）能阻断细胞核和胞质溶胶中核糖核酸外切酶（XRN）的活性。 它刺激气孔关闭，在脱落酸（ABA）信号传递过程中作为第二信使。能够阻断RNA分解代谢。因此，它可以作为生理调节剂，调控聚（ADP-核糖）聚合酶1（PARP1）活性。
腺苷 3′,5′-二磷酸 (PAP)可用于研究羟类固醇磺基转移酶 （如SULT1A1、SULT2A1） 的动力学和作用机理，其是产物抑制剂。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Hao Chen et al.
PloS one, 6(10), e26661-e26661 (2011-10-27)
Abiotic stress, such as drought and high salinity, activates a network of signaling cascades that lead to the expression of many stress-responsive genes in plants. The Arabidopsis FIERY1 (FRY1) protein is a negative regulator of stress and abscisic acid (ABA)
Hao Chen et al.
Plant, cell & environment, 33(12), 2180-2190 (2010-09-03)
The Arabidopsis FIERY1 (FRY1) locus was originally identified as a negative regulator of stress-responsive gene expression and later shown to be required for suppression of RNA silencing. In this study we discovered that the FRY1 locus also regulates lateral root
RISC is a 5? phosphomonoester-producing RNA endonuclease
Martinez J and Tuschl T
Genes & Development, 18(9), 975-980 (2004)
3?-phosphoadenosine 5?-phosphate accumulation delays the circadian system
Litthauer S, et al.
Plant Physiology, 176(4), 3120-3135 (2018)
Hayrettin Ozan Gulcan et al.
Archives of biochemistry and biophysics, 507(2), 232-240 (2010-12-29)
The cytosolic sulfotransferase hSULT2A1 is the major hydroxysteroid (alcohol) sulfotransferase in human liver, and it catalyzes the 3'-phosphoadenosine-5'-phosphosulfate (PAPS)-dependent sulfation of various endogenous hydroxysteroids as well as many xenobiotics that contain alcohol and phenol functional groups. The hSULT2A1 often displays
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