Anti-ASK-1, C-terminal antibody produced in rabbit

ASK1 (Apoptosis Signal-regulating Kinase 1) also known as MAPKKK5 (Mitogen activated protein kinase kinase kinase 5) activates JNK and p38 signaling cascades. ASK-1 is activated in response to stress such as UV and X-ray radiation, proinflammatory cytokines such as TNF-α, heat shock or osmotic shock. Overexpression of ASK1 induces apoptotic cell death. Other signalling molecules such as PP5 and reactive oxygen species regulate the pro-apoptotic signalling by ASK1 hence act as negative regulators. ASK1 has pivotal function also in a broad range of biological activities and aids the cells in adapting to varied stress factors and in induction of immune responses.
Anti-ASK1 specifically recognizes human ASK1 (155 kDa).

synthetic peptide corresponding to amino acids 1356-1375 of the human C-terminal region of ASK1.

A concentration of 1 μg/mL of anti-ASK-1 is recommended for detection by immunoblotting in whole cell extract of SW1353 human chondrosarcoma cells.

Solution in phosphate buffered saline containing 0.02% sodium azide.

Reagent is sufficient for 10 blots.

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