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A6227

Anti-ADAMTS-2, C-Terminal antibody produced in rabbit

Name: Anti-ADAMTS-2, C-Terminal antibody produced in rabbit
Brand: SIGMA

~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution

别名:

Anti-A Disintegrin And Metalloproteinase with ThromboSpondin-2 motif, Anti-Procollagen I N-Proteinase

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关于此项目

UNSPSC Code:

12352203

MDL number:

MFCD04974662

Conjugate:

unconjugated

Clone:

polyclonal

Application:

Citations:

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous glycerol solution

species reactivity

human

concentration

~1 mg/mL

technique(s)

western blot: 1:1,000

UniProt accession no.

O95450

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ADAMTS2(9509)

General description

ADAMTS-2 (or Procollagen I N-Proteinase, PNP) belongs to the ADAM (A Disintegrin And Metalloproteinase) family and has thrombospondin (TS) repeats. ADAMTS-2 has been implicated in collagen synthesis, angiogenesis and development. Alterations in this gene have been linked to Ehlers-Danlos syndrome type VII C, dermatosparaxis, and male infertility. Rabbit Anti-ADAMTS-2 binds to human ADAMTS-2.

By immunoblotting against the reduced protein, the antibody identifies the zymogen form at 130-140 kDa, activated forms at 94-105 kDa (major bands), and breakdown products at 50 kDa, 34 kDa in cell culture media and lysates.

Immunogen

synthetic peptide corresponding to the C-terminal of human ADAMTS-2.

Application

Rabbit Anti-ADAMTS-2, C-terminal antibody can be used for western blot assays at a dilution of 1:1,000.

Physical form

Solution in phosphate buffered saline containing 50% glycerol and 0.05% sodium azide.

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存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

033K0680

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ADAMTS: a novel family of extracellular matrix proteases.

B L Tang

The international journal of biochemistry & cell biology, 33(1), 33-44 (2001-02-13)

ADAMTS (a disintegrin and metalloprotease with thrombospondin motifs) is a novel family of extracellular proteases found in both mammals and invertebrates. Members of the family may be distinguished from the ADAM (a disintegrin and metalloprotease) family members based on the

cDNA cloning and expression of bovine procollagen I N-proteinase: a new member of the superfamily of zinc-metalloproteinases with binding sites for cells and other matrix components.

A Colige et al.

Proceedings of the National Academy of Sciences of the United States of America, 94(6), 2374-2379 (1997-03-18)

Procollagen N-proteinase (EC 3.4.24.14) cleaves the amino-propeptides in the processing of type I and type II procollagens to collagens. Deficiencies of the enzyme cause dermatosparaxis in cattle and sheep, and they cause type VIIC Ehlers-Danlos syndrome in humans, heritable disorders