A6351
A-315456
>98% (HPLC), solid
别名:
N-[3-(cyclohexylidene(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide
方案
>98% (HPLC)
表单
solid
颜色
off-white
溶解性
DMSO: soluble 24 mg/mL
H2O: insoluble
SMILES字符串
CCS(=O)(=O)Nc1cccc(c1)C(=C2/CCCCC2)\c3cnc[nH]3
InChI
1S/C18H23N3O2S/c1-2-24(22,23)21-16-10-6-9-15(11-16)18(17-12-19-13-20-17)14-7-4-3-5-8-14/h6,9-13,21H,2-5,7-8H2,1H3,(H,19,20)
InChI key
MTZVJHSZYMWIAG-UHFFFAOYSA-N
基因信息
human ... ADRA1D(146)
应用
A-315456 is a potent and selective α1D-antagonist that may serve as a useful pharmacological ligand to probe the physiological role of the α(1D)-adrenoceptor subtype in normal and disease states.
生化/生理作用
Selective α1D-adrenoceptor antagonist.
特点和优势
This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
S A Buckner et al.
European journal of pharmacology, 433(1), 123-127 (2002-01-05)
In functional assays, A-315456, N-[3-(cyclohexylidene-(1H-imidazol-4-ylmethyl))phenyl]ethanesulfonamide, behaved as an alpha(1D)-adrenoceptor subtype selective antagonist (pA(2)=8.34) in the rat aorta. It was 83-fold less potent at the alpha(1B)-adrenoceptor subtype expressed in the rat spleen, and was inactive at the alpha(1A)-adrenoceptor subtype expressed in
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