A6352
Anti-ADAMTS-2, Propeptide Region antibody produced in rabbit
~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution
别名:
Anti-A Disintegrin And Metalloproteinase with Thrombospondin-2 motif, Anti-Procollagen I N-Proteinase
生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous glycerol solution
种属反应性
human
浓度
~1 mg/mL
技术
western blot: 1:1,000
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... ADAMTS2(9509)
一般描述
ADAMTS-2 (or Procollagen I N-Proteinase, PNP) belongs to the ADAM (A Disintegrin And Metalloproteinase) family and has thrombospondin (TS) repeats. ADAMTS-2 has been implicated in collagen synthesis, angiogenesis and development. Alterations in this gene have been linked to Ehlers-Danlos syndrome type VII C, dermatosparaxis, and male infertility. Rabbit Anti-ADAMTS-2 binds to human ADAMTS-2.
By immunoblotting against the reduced protein, the antibody identifies the zymogen form at 130-140 kDa, activated forms at 94-105 kDa (major bands), and breakdown products at 50 kDa, 34 kDa in cell culture media and lysates.
免疫原
synthetic peptide corresponding to the propeptide domain of the human ADAMTS-2.
应用
Rabbit Anti-ADAMTS-2 can be used for western blot applications at a dilution of 1:1,000.
外形
Solution in phosphate buffered saline containing 50% glycerol and 0.05% sodium azide.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
A Colige et al.
Proceedings of the National Academy of Sciences of the United States of America, 94(6), 2374-2379 (1997-03-18)
Procollagen N-proteinase (EC 3.4.24.14) cleaves the amino-propeptides in the processing of type I and type II procollagens to collagens. Deficiencies of the enzyme cause dermatosparaxis in cattle and sheep, and they cause type VIIC Ehlers-Danlos syndrome in humans, heritable disorders
B L Tang
The international journal of biochemistry & cell biology, 33(1), 33-44 (2001-02-13)
ADAMTS (a disintegrin and metalloprotease with thrombospondin motifs) is a novel family of extracellular proteases found in both mammals and invertebrates. Members of the family may be distinguished from the ADAM (a disintegrin and metalloprotease) family members based on the
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