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A6355

3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione hydrochloride

Name: 3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione hydrochloride
Brand: SIGMA

powder, ≥98% (HPLC)

别名:

Erk Inhibitor

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关于此项目

经验公式（希尔记法）:

C₁₄H₁₆N₂O₃S · HCl

化学文摘社编号:

294675-79-9

分子量:

328.81

MDL number:

MFCD09038681

NACRES:

NA.77

PubChem Substance ID:

24891079

UNSPSC Code:

12352202

Assay:

≥98% (HPLC)

Form:

powder

Storage condition:

desiccated, under inert gas

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属性

Quality Segment

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated, under inert gas

color

off-white

solubility

DMSO: ≥4 mg/mL

storage temp.

2-8°C

SMILES string

Cl[H].CCOc1ccc(cc1)C=C2SC(=O)N(CCN)C2=O

InChI

1S/C14H16N2O3S.ClH/c1-2-19-11-5-3-10(4-6-11)9-12-13(17)16(8-7-15)14(18)20-12;/h3-6,9H,2,7-8,15H2,1H3;1H/b12-9+;

InChI key

PQVLWVGMXJPJLG-NBYYMMLRSA-N

说明

Application

3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione is an extracellular signal-regulated kinase (ERK) docking domain inhibitor. ERK inhibitors have been used to study traumatic brain injuries.

Biochem/physiol Actions

3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione is extracellular signal-regulated kinase (ERK) docking domain inhibitor. Inhibits ERK binding rather then ERK activity at the ATP domain. IC₅₀ = 25 μM in HeLa, A549, and SUM-159 tumor cells. Currently, no specific inhibitors of the ERK proteins exist. Preferentially binds to ERK2 with a Kd of ~5 μM and prevents its interaction with protein substrates. Shown to block ERK-mediated phosphorylation of ribosomal S6 kinase-1 (RSK-1) and ternary complex factor Elk-1, but exhibits little effect on ERK1/2 phosphorylation by MEK1/2.

Extracellular signal-regulated kinase (ERK) docking domain inhibitor. Inhibits ERK binding rather then ERK activity at the ATP domain. IC₅₀ = 25 μM in HeLa, A549, and SUM-159 tumor cells.

Features and Benefits

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

新产品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000426545

0000402773

101M4628V

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全球贸易项目编号

货号	GTIN
A6355-25MG	04061832433882
A6355-5MG	04061833382080