A6355
3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione hydrochloride
powder, ≥98% (HPLC)
别名:
Erk Inhibitor
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选择规格
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关于此项目
经验公式（希尔记法）:
C14H16N2O3S · HCl
化学文摘社编号:
分子量:
328.81
MDL number:
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated, under inert gas
Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
desiccated, under inert gas
color
off-white
solubility
DMSO: ≥4 mg/mL
storage temp.
2-8°C
SMILES string
Cl[H].CCOc1ccc(cc1)C=C2SC(=O)N(CCN)C2=O
InChI
1S/C14H16N2O3S.ClH/c1-2-19-11-5-3-10(4-6-11)9-12-13(17)16(8-7-15)14(18)20-12;/h3-6,9H,2,7-8,15H2,1H3;1H/b12-9+;
InChI key
PQVLWVGMXJPJLG-NBYYMMLRSA-N
Application
3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione is an extracellular signal-regulated kinase (ERK) docking domain inhibitor. ERK inhibitors have been used to study traumatic brain injuries.
Biochem/physiol Actions
3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione is extracellular signal-regulated kinase (ERK) docking domain inhibitor. Inhibits ERK binding rather then ERK activity at the ATP domain. IC50 = 25 μM in HeLa, A549, and SUM-159 tumor cells. Currently, no specific inhibitors of the ERK proteins exist. Preferentially binds to ERK2 with a Kd of ~5 μM and prevents its interaction with protein substrates. Shown to block ERK-mediated phosphorylation of ribosomal S6 kinase-1 (RSK-1) and ternary complex factor Elk-1, but exhibits little effect on ERK1/2 phosphorylation by MEK1/2.
Extracellular signal-regulated kinase (ERK) docking domain inhibitor. Inhibits ERK binding rather then ERK activity at the ATP domain. IC50 = 25 μM in HeLa, A549, and SUM-159 tumor cells.
Features and Benefits
This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable