A6376
N-乙酰基-L-色氨酸
≥99% (TLC), suitable for ligand binding assays
产品名称
N-乙酰基-L-色氨酸,
方案
≥99% (TLC)
表单
powder
技术
ligand binding assay: suitable
颜色
white to off-white
储存温度
2-8°C
SMILES字符串
CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O
InChI
1S/C13H14N2O3/c1-8(16)15-12(13(17)18)6-9-7-14-11-5-3-2-4-10(9)11/h2-5,7,12,14H,6H2,1H3,(H,15,16)(H,17,18)/t12-/m0/s1
InChI key
DZTHIGRZJZPRDV-LBPRGKRZSA-N
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生化/生理作用
N-乙酰基-L-色氨酸（NAT, Ac-Trp-OH）可用作底物PNK1速激肽受体拮抗剂。N-乙酰基-L-色氨酸也作为一种竞争性抑制剂，用于鉴定、区分和表征色氨酸酶。
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
James J Donkin et al.
Journal of neurotrauma, 28(2), 217-224 (2010-12-24)
Previous studies have demonstrated that the compound N-acetyl-L-tryptophan (NAT) reduces brain edema and improves functional outcome following traumatic brain injury (TBI). In this study we examined whether this effect was mediated via the neurokinin-1 receptor, and whether there was an
New tryptophanase inhibitors: towards prevention of bacterial biofilm formation.
Scherzer R, Gdalevsky GY, et al.
Journal of Enzyme Inhibition, 24, 350-355 (2009)
Renée J Turner et al.
Brain research, 1393, 84-90 (2011-04-07)
Previous studies have suggested that substance P (SP) plays a critical role in the development of brain oedema and functional deficits following traumatic brain injury and that SP receptor antagonism may improve outcome. No studies have described such a role
M Lehnig et al.
Free radical research, 41(5), 523-535 (2007-04-25)
Tryptophan and melatonin are nitrated by peroxynitrite; tryptophan residues in proteins are susceptible to attack by reactive nitrogen species. Nitrated tryptophan might therefore be used as a biomarker for the involvement of reactive species derived from nitrogen oxide in a
Kate M Lewis et al.
Anti-cancer drugs, 24(4), 344-354 (2013-02-15)
Emend, an NK1 antagonist, and dexamethasone are used to treat complications associated with metastatic brain tumours and their treatment. It has been suggested that these agents exert anticancer effects apart from their current use. The effects of the NK1 antagonists
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