A6612
白蛋白 人
recombinant, expressed in rice, lyophilized powder
别名:
rHSA
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关于此项目
经验公式（希尔记法）:
C2936H4624N786O889S41
化学文摘社编号:
分子量:
66471.53
NACRES:
NA.25
UNSPSC Code:
12352202
EC Number:
274-272-6
MDL number:
InChI key
QYSGYZVSCZSLHT-UHFFFAOYSA-N
InChI
1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11
biological source
human
recombinant
expressed in rice
assay
≥99% (PAGE)
form
lyophilized powder
mol wt
monomer ~67 kDa
composition
Protein, ≥90% biuret
technique(s)
cell culture | mammalian: suitable
impurities
≤6.7 EU/g Endotoxin
pH range
6.5-7.2
UniProt accession no.
storage temp.
2-8°C
Gene Information
human ... ALB(213)
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General description
Human serum albumin (HSA) is encoded by the gene mapped to human chromosome 4. Albumin is a globular protein with 585 amino acids. It is the most prominent protein in human sera. Albumin constitutes total concentration of about 60% of the total proteins in the blood serum. The encoded protein contains three globular domains that resemble each other in structure, each containing two subdomains. Albumins are soluble monomeric proteins found in the body fluids and tissues of animals and in some plant seeds.
Application
该重组变异建议用于：吸收、分散、代谢和排泄（ADME）药理学研究；细胞培养；药物递送研究；细胞冻存。
Biochem/physiol Actions
白蛋白是可见于动物体液和组织及部分植物种子的一类可溶性单体蛋白。 血清白蛋白可作为类固醇、脂肪酸和甲状腺激素的载体蛋白。 血清白蛋白在调节血液的胶体渗透压方面也至关重要。
Serum albumin functions as a carrier protein for steroids, fatty acids and thyroid hormones. Serum albumins are also vital in regulating the colloidal osmotic pressures of blood. This globular protein is broadly used to treat serious burn injuries, hemorrhagic shock, hypoproteinemia, fetal erythroblastosis and ascites caused by liver cirrhosis. HSA has various biological applications, such as carrier of oxygen, nanodelivery of drugs and fusion of peptides.
Other Notes
更多信息参见人血清白蛋白。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Large-scale production of functional human serum albumin from transgenic rice seeds.
He Y, et al.
Proceedings of the National Academy of Sciences of the USA, 201109736-201109736 (2011)
Large-scale production of functional human serum albumin from transgenic rice seeds.
He Y, et al.
Proceedings of the National Academy of Sciences of the USA, 201109736-201109736 (2011)
Hung X Nguyen et al.
Nature communications, 13(1), 620-620 (2022-02-04)
Therapies for cardiac arrhythmias could greatly benefit from approaches to enhance electrical excitability and action potential conduction in the heart by stably overexpressing mammalian voltage-gated sodium channels. However, the large size of these channels precludes their incorporation into therapeutic viral
Ilya Y Shadrin et al.
Nature communications, 8(1), 1825-1825 (2017-12-01)
Despite increased use of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) for drug development and disease modeling studies, methods to generate large, functional heart tissues for human therapy are lacking. Here we present a "Cardiopatch" platform for 3D culture and
The three recombinant domains of human serum albumin structural characterization and ligand binding properties.
Dockal M, et al.
The Journal of Biological Chemistry, 274(41), 29303-29310 (1999)
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