A6671
放线酰胺素
≥98% (TLC), powder, leucine aminopeptidase inhibitor
别名:
3-[[1-[(2-(羟甲基)-1-吡咯烷基)羰基]-2-甲基苯基]氨基甲酰基]辛异羟肟酸
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关于此项目
经验公式(希尔记法):
C19H35N3O5
化学文摘社编号:
分子量:
385.50
Beilstein:
1555250
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
放线酰胺素,
生物来源
synthetic (organic)
质量水平
方案
≥98% (TLC)
表单
powder
溶解性
ethanol: 50 mg/mL, clear, colorless
抗生素抗菌谱
Gram-negative bacteria
Gram-positive bacteria
作用机制
enzyme | inhibits
储存温度
−20°C
SMILES字符串
CCCCCC(CC(=O)NO)C(=O)NC(C(C)C)C(=O)N1CCCC1CO
InChI
1S/C19H35N3O5/c1-4-5-6-8-14(11-16(24)21-27)18(25)20-17(13(2)3)19(26)22-10-7-9-15(22)12-23/h13-15,17,23,27H,4-12H2,1-3H3,(H,20,25)(H,21,24)
InChI key
XJLATMLVMSFZBN-UHFFFAOYSA-N
基因信息
human ... ANPEP(290), DPP4(1803), ECE1(1889), LAP3(51056)
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储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Christopher D Goodman et al.
eLife, 9 (2020-07-18)
The antibiotic actinonin kills malaria parasites (Plasmodium falciparum) by interfering with apicoplast function. Early evidence suggested that actinonin inhibited prokaryote-like post-translational modification in the apicoplast; mimicking its activity against bacteria. However, Amberg Johnson et al. (2017) identified the metalloprotease TgFtsH1
Actinonin, a naturally occurring antibacterial agent, is a potent deformylase inhibitor
Chen DZ, et al.
Biochemistry, 39(6), 1256-1262 (2000)
Ectodomain shedding of CD99 within highly conserved regions is mediated by the metalloprotease meprin $\beta$ and promotes transendothelial cell migration
Bedau T, et al.
Faseb Journal, 31(3), 1226-1237 (2016)
Jessica Bien et al.
The Journal of biological chemistry, 287(40), 33304-33313 (2012-08-11)
The amyloid β (Aβ) peptide, which is abundantly found in the brains of patients suffering from Alzheimer disease, is central in the pathogenesis of this disease. Therefore, to understand the processing of the amyloid precursor protein (APP) is of critical
Ligand-induced changes in the structure and dynamics of Escherichia coli peptide deformylase
Amero CD, et al.
Biochemistry, 48(32), 7595-7607 (2009)
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