A6671
放线酰胺素
≥98% (TLC), powder, leucine aminopeptidase inhibitor
别名:
3-[[1-[（2-（羟甲基）-1-吡咯烷基）羰基]-2-甲基苯基]氨基甲酰基]辛异羟肟酸
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关于此项目
经验公式（希尔记法）:
C19H35N3O5
化学文摘社编号:
分子量:
385.50
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Beilstein/REAXYS Number:
1555250
产品名称
放线酰胺素,
InChI
1S/C19H35N3O5/c1-4-5-6-8-14(11-16(24)21-27)18(25)20-17(13(2)3)19(26)22-10-7-9-15(22)12-23/h13-15,17,23,27H,4-12H2,1-3H3,(H,20,25)(H,21,24)
SMILES string
CCCCCC(CC(=O)NO)C(=O)NC(C(C)C)C(=O)N1CCCC1CO
InChI key
XJLATMLVMSFZBN-UHFFFAOYSA-N
biological source
synthetic (organic)
assay
≥98% (TLC)
form
powder
solubility
ethanol: 50 mg/mL, clear, colorless
antibiotic activity spectrum
Gram-negative bacteria
Gram-positive bacteria
mode of action
enzyme | inhibits
storage temp.
−20°C
Quality Level
Gene Information
human ... ANPEP(290), DPP4(1803), ECE1(1889), LAP3(51056)
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Jennifer Hamner et al.
Scientific reports, 10(1), 6358-6358 (2020-04-15)
Vaginal delivery with obstetrical trauma is a risk factor for pelvic organ prolapse later in life. Loss of fibulin-5 (FBLN5), an elastogenesis-promoting cellular matrix protein, results in prolapse in mice. Here, we evaluated effects of pregnancy, parturition, and obstetrical injury
Ligand-induced changes in the structure and dynamics of Escherichia coli peptide deformylase
Amero CD, et al.
Biochemistry, 48(32), 7595-7607 (2009)
Christopher D Goodman et al.
eLife, 9 (2020-07-18)
The antibiotic actinonin kills malaria parasites (Plasmodium falciparum) by interfering with apicoplast function. Early evidence suggested that actinonin inhibited prokaryote-like post-translational modification in the apicoplast; mimicking its activity against bacteria. However, Amberg Johnson et al. (2017) identified the metalloprotease TgFtsH1
Sonia Fieulaine et al.
PLoS biology, 9(5), e1001066-e1001066 (2011-06-02)
For several decades, molecular recognition has been considered one of the most fundamental processes in biochemistry. For enzymes, substrate binding is often coupled to conformational changes that alter the local environment of the active site to align the reactive groups
Diana Mader et al.
Microbes and infection, 12(5), 415-419 (2010-02-17)
The biosynthesis of proteins with N-terminal formylated methionine residues and subsequent protein deformylation are unique and invariant bacterial processes. They are exploited by the capacity of the human innate immune system to sense formylated peptides (FPs) and targeted by the
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