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A6671

放线酰胺素

Name: 放线酰胺素
Brand: SIGMA

≥98% (TLC), powder, leucine aminopeptidase inhibitor

别名:

3-[[1-[（2-（羟甲基）-1-吡咯烷基）羰基]-2-甲基苯基]氨基甲酰基]辛异羟肟酸

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关于此项目

经验公式（希尔记法）:

C₁₉H₃₅N₃O₅

化学文摘社编号:

13434-13-4

分子量:

385.50

NACRES:

NA.77

PubChem Substance ID:

24278232

UNSPSC Code:

12352200

MDL number:

MFCD00080257

Beilstein/REAXYS Number:

1555250

Assay:

≥98% (TLC)

Form:

powder

Quality level:

200

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产品名称

放线酰胺素,

biological source

synthetic (organic)

Quality Level

200

assay

≥98% (TLC)

form

powder

solubility

ethanol: 50 mg/mL, clear, colorless

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

enzyme | inhibits

storage temp.

−20°C

SMILES string

CCCCCC(CC(=O)NO)C(=O)NC(C(C)C)C(=O)N1CCCC1CO

InChI

1S/C19H35N3O5/c1-4-5-6-8-14(11-16(24)21-27)18(25)20-17(13(2)3)19(26)22-10-7-9-15(22)12-23/h13-15,17,23,27H,4-12H2,1-3H3,(H,20,25)(H,21,24)

InChI key

XJLATMLVMSFZBN-UHFFFAOYSA-N

Gene Information

human ... ANPEP(290), DPP4(1803), ECE1(1889), LAP3(51056)

General description

化学结构：肽

Application

放线酰胺素已被用作抑制C57BL/6小鼠中meprinβ活性的对照。它还已用于通过15N NMR波谱和等温滴定研究EcPDF与放线酰胺素的高亲和力交互效应。

Biochem/physiol Actions

放线酰胺素对肽脱甲酰基酶（PDF）具有抑制作用。对革兰氏阳性和苛养型革兰氏阴性微生物有效。

放线酰胺素是亮氨酸氨基肽酶的抑制剂。放线酰胺素还被用于改善抗菌活性和抗肥胖疗法。

Features and Benefits

该化合物是受体分类及信号转导手册上神经肽酶页面上的特色化合物。想要浏览手册的其他页面，请单击此处。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000548798

0000520969

0000520970

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Ectodomain shedding of CD99 within highly conserved regions is mediated by the metalloprotease meprin $\beta$ and promotes transendothelial cell migration

Bedau T, et al.

Faseb Journal, 31(3), 1226-1237 (2016)

Actinonin, a naturally occurring antibacterial agent, is a potent deformylase inhibitor

Chen DZ, et al.

Biochemistry, 39(6), 1256-1262 (2000)

Protease Inhibition Improves Healing of The Vaginal Wall after Obstetrical Injury: Results from a Preclinical Animal Model.

Jennifer Hamner et al.

Scientific reports, 10(1), 6358-6358 (2020-04-15)

Vaginal delivery with obstetrical trauma is a risk factor for pelvic organ prolapse later in life. Loss of fibulin-5 (FBLN5), an elastogenesis-promoting cellular matrix protein, results in prolapse in mice. Here, we evaluated effects of pregnancy, parturition, and obstetrical injury

A single point mutation in the Plasmodium falciparum FtsH1 metalloprotease confers actinonin resistance.

Christopher D Goodman et al.

eLife, 9 (2020-07-18)

The antibiotic actinonin kills malaria parasites (Plasmodium falciparum) by interfering with apicoplast function. Early evidence suggested that actinonin inhibited prokaryote-like post-translational modification in the apicoplast; mimicking its activity against bacteria. However, Amberg Johnson et al. (2017) identified the metalloprotease TgFtsH1

Ligand-induced changes in the structure and dynamics of Escherichia coli peptide deformylase

Amero CD, et al.

Biochemistry, 48(32), 7595-7607 (2009)

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全球贸易项目编号

货号	GTIN
A6671-25MG	04061833382646
A6671-10MG	04061833258477

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