表单
solid
储存温度
2-8°C
SMILES字符串
CC(=O)OC[C@H]1OC(OC(C)=O)[C@H](NC(=O)N=[N+]=[N-])[C@@H](OC(C)=O)[C@@H]1OC(C)=O
InChI
1S/C15H20N4O10/c1-6(20)25-5-10-12(26-7(2)21)13(27-8(3)22)11(17-15(24)18-19-16)14(29-10)28-9(4)23/h10-14H,5H2,1-4H3,(H,17,24)/t10-,11-,12-,13-,14?/m1/s1
InChI key
MRRKYEUMMAEYHG-GNMOMJPPSA-N
应用
非天然叠氮基糖，可以代谢方式引入模式生物，随后并入到聚糖结构。叠氮基可与结合到试剂的膦反应，用于可视化或选择性捕获。与 FLAG®-Phosphine™ (GPHOS1) 结合使用，与其他许多 FLAG 工具在两种应用下都兼容。
法律信息
FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Wenshuang Wang et al.
Nature communications, 11(1), 5915-5915 (2020-11-22)
Proteoglycans (PGs) are composed of a core protein and one or more chains of glycosaminoglycans (GAGs). The highly heterogeneous GAG chains play an irreplaceable role in the functions of PGs. However, the lack of an approach to control the exact
Eiichi Hashimoto et al.
iScience, 23(7), 101299-101299 (2020-07-08)
The proteasome is a therapeutic target in cancer, but resistance to proteasome inhibitors often develops owing to the induction of compensatory pathways. Through a genome-wide siRNA screen combined with RNA sequencing analysis, we identified hexokinase and downstream O-GlcNAcylation as cell
Sudharsana R Ande et al.
PloS one, 4(2), e4586-e4586 (2009-02-25)
Prohibitin (PHB or PHB1) is an evolutionarily conserved, multifunctional protein which is present in various cellular compartments including the plasma membrane. However, mechanisms involved in various functions of PHB are not fully explored yet. Here we report for the first
Yubo Liu et al.
Scientific reports, 7(1), 12334-12334 (2017-09-28)
O-GlcNAc transferase (OGT) plays an important role in regulating numerous cellular processes through reversible post-translational modification of nuclear and cytoplasmic proteins. However, the function of O-GlcNAcylation is still not well understood. Cell permeable OGT inhibitors are needed to manipulate O-GlcNAcylation
C R Bertozzi et al.
Science (New York, N.Y.), 291(5512), 2357-2364 (2001-03-28)
Chemical tools have proven indispensable for studies in glycobiology. Synthetic oligosaccharides and glycoconjugates provide materials for correlating structure with function. Synthetic mimics of the complex assemblies found on cell surfaces can modulate cellular interactions and are under development as therapeutic
商品
Glycans play a key role in protein structure and disease; representation on cell surfaces is the glycome.
GlycoProfile™ Azido Sugar portfolio offers peracetylated azido sugars for glycan structure modification via chemical or biosynthetic pathways.
蛋白质的结构修饰对于活细胞是必不可少的。发生调节异常时，它们往往是会引发疾病。聚糖是生物系统中许多结构变异的原因，它们在细胞表面的表现通常被称为“糖”。
相关内容
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