Name: Anthopleurin-A trifluoroacetate salt
Brand: SIGMA

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About This Item

经验公式（希尔记法）:

C₂₂₀H₃₂₆N₆₄O₆₇S₆ · xC₂HF₃O₂

分子量:

5131.72 (free base basis)

MDL编号:

MFCD00240628

UNSPSC代码:

12352202

NACRES:

NA.77

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方案

>88% (HPLC)

表单

solid

储存温度

−20°C

Amino Acid Sequence

Gly-Val-Ser-Cys-Leu-Cys-Asp-Ser-Asp-Gly-Pro-Ser-Val-Arg-Gly-Asn-Thr-Leu-Ser-Gly-Thr-Leu-Trp-Leu-Tyr-Pro-Ser-Gly-Cys-Pro-Ser-Gly-Trp-His-Asn-Cys-Lys-Ala-His-Gly-Pro-Thr-Ile-Gly-Trp-Cys-Cys-Lys-Gln [Disulfide bridges: 4-46, 6-36, 29-47]

一般描述

Synthetic peptide toxin that was originally isolated from the sea anemone, Anthopleura xanthogrammica.

Synthetic peptide toxin.

应用

Anthopleurin-A is a toxin used to study the gating mechanisms of sodium channels. Anthopleurin-A slows the repolarization phase of nerve and muscle action potentials by inactivating the sodium channel.

生化/生理作用

Anthopleurin-A slows the repolarization phase of nerve and muscle action potentials by inactivating the sodium channel. Anthopleurin-A shows a preference towards cardiac channels over the neuronal sodium channels. It is a toxin used to study the gating mechanisms of sodium channels.

Shown to have inotropic effects and not chronotropic effects on mammalian heart preparations.