A7475
Anthopleurin-A trifluoroacetate salt
>88% (HPLC)
别名:
AP-A trifluoroacetate salt, Anthopleura toxin A trifluoroacetate salt
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关于此项目
经验公式（希尔记法）:
C220H326N64O67S6 · xC2HF3O2
分子量:
5131.72 (free base basis)
UNSPSC Code:
12352202
NACRES:
NA.77
MDL number:
Assay:
>88% (HPLC)
Form:
solid
assay
>88% (HPLC)
form
solid
storage temp.
−20°C
General description
Synthetic peptide toxin that was originally isolated from the sea anemone, Anthopleura xanthogrammica.
Synthetic peptide toxin.
Application
Anthopleurin-A is a toxin used to study the gating mechanisms of sodium channels. Anthopleurin-A slows the repolarization phase of nerve and muscle action potentials by inactivating the sodium channel.
Biochem/physiol Actions
Anthopleurin-A slows the repolarization phase of nerve and muscle action potentials by inactivating the sodium channel. Anthopleurin-A shows a preference towards cardiac channels over the neuronal sodium channels. It is a toxin used to study the gating mechanisms of sodium channels.
Shown to have inotropic effects and not chronotropic effects on mammalian heart preparations.
Other Notes
supplied as trifluoroacetate salt
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
M J Scanlon et al.
Protein science : a publication of the Protein Society, 3(7), 1121-1124 (1994-07-01)
Anthopleurin-A (AP-A) is a member of a family of sea anemone-derived polypeptides that interact with sodium channels in a voltage-dependent manner, producing a positive inotropic effect on the mammalian heart. There has been considerable interest in this molecule as a
P K Pallaghy et al.
Biochemistry, 34(11), 3782-3794 (1995-03-21)
The three-dimensional structure in aqueous solution of the 49-residue polypeptide anthopleurin-A (AP-A), from the sea anemone Anthopleura xanthogrammica, has been determined from 1H NMR data. A restraint set consisting of 411 interproton distance restraints inferred from NOEs and 19 backbone
Daisuke Izumi et al.
Heart rhythm, 9(5), 796-803 (2011-11-30)
Previous studies have showed that the interval between the peak and the end of the T wave (Tp-e) is a marker of transmural dispersion of ventricular repolarization. We studied the relationship between (a) the Tp-e on local pseudo transmural electrograms
Y Pichon
Journal of physiology, Paris, 89(4-6), 171-180 (1995-01-01)
The physiological function of the axon is to conduct short all-or-none action potentials from their site of initiation (usually the cell body) to the synapse. To ensure this function, both passive and active biophysical properties of the axons are tuned
W Shimizu et al.
Circulation, 96(6), 2038-2047 (1997-10-10)
This study examines the contribution of transmural heterogeneity of transmembrane activity to phenotypic T-wave patterns and the effects of pacing and of sodium channel block under conditions mimicking HERG and SCN5A defects linked to the congenital long-QT syndrome (LQTS). A
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