A7762
L-烯丙基甘氨酸
≥99% (TLC), powder
别名:
(S)-(-)-2-氨基-4-戊烯酸, L-2-氨基-4-戊烯酸
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关于此项目
经验公式（希尔记法）:
C5H9NO2
化学文摘社编号:
分子量:
115.13
PubChem Substance ID:
UNSPSC Code:
12352200
Beilstein/REAXYS Number:
1721512
MDL number:
SMILES string
N[C@@H](CC=C)C(O)=O
InChI
1S/C5H9NO2/c1-2-3-4(6)5(7)8/h2,4H,1,3,6H2,(H,7,8)/t4-/m0/s1
InChI key
WNNNWFKQCKFSDK-BYPYZUCNSA-N
assay
≥99% (TLC)
form
powder
optical activity
[α]25/D −37.1°, c = 4 in H2O(lit.)
color
white
solubility
H2O: 100 mg/mL
storage temp.
room temp
Gene Information
human ... GAD1(2571), GAD2(2572)
Biochem/physiol Actions
Glutamic acid decarboxylase inhibitor.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
J Thomas et al.
Physiology & behavior, 49(6), 1181-1183 (1991-06-01)
The possibility that a sex difference in gamma-aminobutyric acid (GABA) activity might be an underlying cause of the previously reported sex differences in picrotoxin-induced seizures was investigated. Male and female rats were injected (IP) with the GABA antagonist, L-allylglycine (100
V M Abshire et al.
Neuropharmacology, 27(11), 1171-1177 (1988-11-01)
Injection of the GABA antagonist, bicuculline methiodide into the posterior hypothalamus of rats has been shown to cause marked increases in heart rate and lesser elevations in blood pressure. Allylglycine is a potent inhibitor of the synthetic enzyme for GABA
M Bottlaender et al.
European journal of pharmacology, 321(1), 13-17 (1997-02-19)
The influence of decreased endogenous gamma-aminobutyric acid (GABA) concentration on benzodiazepine receptor function was studied in the brain of living baboons. Positron emission tomography and the radiotracer [11C]flumazenil combined with electroencephalography were used to determine the pharmacological properties of two
M Iijima et al.
British journal of pharmacology, 171(14), 3511-3525 (2014-03-25)
Vasopressin V1B receptor antagonists may be effective for the treatment of depression and anxiety and the objective of this study was to characterize the pharmacological profiles of two newly synthesized arginine vasopressin receptor 1B (V1B receptor) antagonists, TASP0233278 and TASP0390325.
Tracie A Paine et al.
Pharmacology, biochemistry, and behavior, 135, 97-104 (2015-06-06)
Cortical GABA regulates a number of cognitive functions including attention and working memory and is dysregulated in a number of psychiatric conditions. In schizophrenia for example, changes in GABA neurons [reduced expression of glutamic acid decarboxylase (GAD), parvalbumin (PV) and
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