A7856
阿西莫司
≥99% (TLC)
别名:
2-羧基-5-甲基吡嗪4-氧化物, 5-甲基吡嗪羧酸4-氧化物
质量水平
方案
≥99% (TLC)
表单
powder
颜色
off-white to faint yellow
mp
177-180 °C
储存温度
2-8°C
SMILES字符串
[n+]1(c(cncc1C(=O)O)C)[O-]
InChI
1S/C6H6N2O3/c1-4-2-7-3-5(6(9)10)8(4)11/h2-3H,1H3,(H,9,10)
InChI key
DNRXJHATQULEHC-UHFFFAOYSA-N
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生化/生理作用
已经研究了烟酸衍生的血管舒张剂的降脂作用。
阿昔莫司又称氧甲吡嗪,是一种烟酸类似物。它可用作抗脂解药和血管扩张剂。阿西莫司可用于胰岛素和生长素释放肽相关的各种代谢研究。它可降低总胆固醇和总甘油三酯,从而有助于治疗高脂血症。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Hanna-Riikka Lehto et al.
The Journal of clinical endocrinology and metabolism, 97(9), 3277-3284 (2012-07-05)
We tested the hypothesis that a persistent reduction in free fatty acid (FFA) levels improves cardiac function and systemic insulin sensitivity via a reduction in the myocardial and skeletal muscle adiposities and a modulation in adipokine release. Study subjects (body
Effects of acipimox on serum lipids, lipoproteins and lipolytic enzymes in hypertriglyceridemia
Taskinen MR and Nikkila EA
Atherosclerosis, 69(2-3), 249-255 (1988)
Acyl ghrelin induces insulin resistance independently of GH, cortisol, and free fatty acids
Vestergaard ET, et al.
Scientific Reports, 7, 42706-42706 (2017)
Ee L Lim et al.
Clinical science (London, England : 1979), 121(4), 169-177 (2011-03-11)
Suppression of lipolysis by acipimox is known to improve insulin-stimulated glucose disposal, and this is an important phenomenon. The mechanism has been assumed to be an enhancement of glucose storage as glycogen, but no direct measurement has tested this concept
J Huang et al.
Drug research, 63(2), 79-83 (2013-03-01)
The study was designed to compare the pharmacokinetic parameters and relative bioavailability of a newly generic acipimox 250-mg tablets (test formulation) with a branded 250-mg tablets (reference formulation). A single-dose, randomized-sequence, 2-way crossover study was conducted in 20 healthy Chinese
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