A7856
阿西莫司
≥99% (TLC)
别名:
2-羧基-5-甲基吡嗪4-氧化物, 5-甲基吡嗪羧酸4-氧化物
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关于此项目
经验公式（希尔记法）:
C6H6N2O3
化学文摘社编号:
分子量:
154.12
MDL number:
UNSPSC Code:
12352205
EC Number:
256-928-3
NACRES:
NA.79
SMILES string
[n+]1(c(cncc1C(=O)O)C)[O-]
InChI key
DNRXJHATQULEHC-UHFFFAOYSA-N
InChI
1S/C6H6N2O3/c1-4-2-7-3-5(6(9)10)8(4)11/h2-3H,1H3,(H,9,10)
assay
≥99% (TLC)
form
powder
color
off-white to faint yellow
mp
177-180 °C
storage temp.
2-8°C
Quality Level
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Biochem/physiol Actions
已经研究了烟酸衍生的血管舒张剂的降脂作用。
阿昔莫司又称氧甲吡嗪，是一种烟酸类似物。它可用作抗脂解药和血管扩张剂。阿西莫司可用于胰岛素和生长素释放肽相关的各种代谢研究。它可降低总胆固醇和总甘油三酯，从而有助于治疗高脂血症。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Ee L Lim et al.
Clinical science (London, England : 1979), 121(4), 169-177 (2011-03-11)
Suppression of lipolysis by acipimox is known to improve insulin-stimulated glucose disposal, and this is an important phenomenon. The mechanism has been assumed to be an enhancement of glucose storage as glycogen, but no direct measurement has tested this concept
Feipeng Jin et al.
Biochemical and biophysical research communications, 428(1), 86-92 (2012-10-13)
Saturated fatty acids (FA) have been linked to an increased risk of cardiovascular disease. The effects of acipimox, a FA-lowering agent, on palmitate- (an important saturated fatty acid) stimulated atherosclerosis remains to be elucidated. We investigated the effects of acipimox
Acyl ghrelin induces insulin resistance independently of GH, cortisol, and free fatty acids
Vestergaard ET, et al.
Scientific Reports, 7, 42706-42706 (2017)
Hanna-Riikka Lehto et al.
The Journal of clinical endocrinology and metabolism, 97(9), 3277-3284 (2012-07-05)
We tested the hypothesis that a persistent reduction in free fatty acid (FFA) levels improves cardiac function and systemic insulin sensitivity via a reduction in the myocardial and skeletal muscle adiposities and a modulation in adipokine release. Study subjects (body
J Huang et al.
Drug research, 63(2), 79-83 (2013-03-01)
The study was designed to compare the pharmacokinetic parameters and relative bioavailability of a newly generic acipimox 250-mg tablets (test formulation) with a branded 250-mg tablets (reference formulation). A single-dose, randomized-sequence, 2-way crossover study was conducted in 20 healthy Chinese
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