A8676
阿普洛尔 盐酸盐
≥98% (TLC), powder
别名:
1-(o-烯丙基苯氧基)-3-(异丙基氨基)-2-丙醇 盐酸盐
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关于此项目
经验公式（希尔记法）:
C15H23NO2 · HCl
化学文摘社编号:
分子量:
285.81
UNSPSC Code:
12352200
PubChem Substance ID:
EC Number:
237-244-4
MDL number:
InChI key
RRCPAXJDDNWJBI-UHFFFAOYSA-N
InChI
1S/C15H23NO2.ClH/c1-4-7-13-8-5-6-9-15(13)18-11-14(17)10-16-12(2)3;/h4-6,8-9,12,14,16-17H,1,7,10-11H2,2-3H3;1H
SMILES string
Cl[H].CC(C)NCC(O)COc1ccccc1CC=C
assay
≥98% (TLC)
form
powder
color
off-white
solubility
H2O: 50 mg/mL
Gene Information
human ... ADRB1(153), ADRB2(154)
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Application
Alprenolol is a nonselective β-blocker and a serotonin 5HT1A receptor antagonist.
Biochem/physiol Actions
β1- and β2-adrenoceptor antagonist.
A J Surman et al.
Journal of cardiovascular pharmacology, 21(1), 35-39 (1993-01-01)
We studied the effects of alprenolol and bromoacetylalprenololmenthane (BAAM) on rat left atria. Alprenolol and BAAM at 10(-7), 3 x 10(-7), and 10(-6) M inhibited the cardiac stimulation response slightly, which is indicative of membrane-stabilizing activity independent of beta-adrenoceptor blockade.
Y Shirayama et al.
European journal of pharmacology, 331(2-3), 319-323 (1997-07-23)
Desipramine, imipramine, clomipramine, (-)-propranolol, (-)-alprenolol, (+/-)-pentazocine and risperidone caused a concentration-dependent inhibition of 6 nM [3H]DTG (1,3-di-o-tolylguanidine)-defined sigma (sigma) binding with Ki values of about 0.5-2.5 microM in well-washed homogenates obtained from rat cerebral cortex. The saturation studies revealed that
(-)Alprenolol potentiates the disrupting effects of dizocilpine on sensorimotor function in the rat.
J Zhang et al.
Psychopharmacology, 132(3), 281-288 (1997-08-01)
The beta-adrenoceptor antagonist as well as serotonin 5-HT1 receptor antagonist, (-)alprenolol, was found to potentiate the disrupting effect of the noncompetitive NMDA receptor antagonist, dizocilpine, on prepulse inhibition (PPI) of the acoustic startle response (ASR) in the rat. The facilitating
Xiaogang Hu et al.
Journal of chromatography. A, 1216(2), 190-197 (2008-12-17)
An improved multiple co-polymerization technique was developed to prepare a novel molecularly imprinted polymer (MIP)-coated solid-phase microextraction (SPME) fiber with propranolol as template. Investigation was performed for the characteristics and application of the fibers. The MIP coating was highly crosslinked
Ron O Dror et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(32), 13118-13123 (2011-07-23)
How drugs bind to their receptors--from initial association, through drug entry into the binding pocket, to adoption of the final bound conformation, or "pose"--has remained unknown, even for G-protein-coupled receptor modulators, which constitute one-third of all marketed drugs. We captured
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