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Merck
CN

A8681

3′-唾液酸乳糖

from bovine milk or colostrum, ≥97% (HPLC)

别名:

α-NeuNAc-(2→3)-β-D-Gal-(1→4)-D-Glc, 3′-SL, 3′-唾液酸-D-乳糖, 3&8242-N-乙酰神经氨酸乙酯-D-乳糖 钠盐, NANA-乳糖

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关于此项目

经验公式（希尔记法）:
C23H39NO19
化学文摘社编号:
35890-38-1
分子量:
633.55
Beilstein:
75357
MDL编号:
MFCD00166999
UNSPSC代码:
12352201
PubChem化学物质编号:
24891358
NACRES:
NA.25

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生物来源

bovine milk or colostrum

方案

≥97% (HPLC)

表单

powder

颜色

white

溶解性

water: 20 mg/mL, clear, colorless

痕量阳离子

Na: 3.1-4.7%

储存温度

−20°C

SMILES字符串

[Na+].[H]C(=O)[C@H](O)[C@@H](O)[C@H](O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O[C@@]2(C[C@H](O)[C@@H](NC(C)=O)[C@@H](O2)[C@H](O)[C@H](O)CO)C([O-])=O)[C@H]1O)[C@H](O)CO

InChI

1S/C23H39NO19.Na/c1-7(29)24-13-8(30)2-23(22(38)39,42-19(13)15(35)10(32)4-26)43-20-16(36)12(6-28)40-21(17(20)37)41-18(11(33)5-27)14(34)9(31)3-25;/h3,8-21,26-28,30-37H,2,4-6H2,1H3,(H,24,29)(H,38,39);/q;+1/p-1/t8-,9-,10+,11+,12+,13+,14+,15+,16-,17+,18+,19+,20-,21-,23-;/m0./s1

InChI key

LTWFUJWFLMHANB-TZCPRLTCSA-M

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相关类别

应用

3′-唾液乳糖是一种化合物，在乙酰神经氨酰（NANA）单元中，在 3 号位连接乳糖的半乳糖单元。在 6′-唾液乳糖中，在 6 号位产生这种连接。3′-唾液酸乳糖和 6′-唾液酸乳糖用于区分和表征病毒（如流感病毒和鼻炎病毒）的结合域，它们能识别 NANA 覆盖的细胞表面受体。3′-唾液乳糖和 6′-唾液乳糖用作测量其在牛奶和初乳等材料中的含量的分析方法中的参考化合物。

其他说明

为了全面了解我们针对客户研究提供的各种寡糖产品，建议您访问我们的碳水化合物分类页面。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SLBZ2298
SLBX4359
SLBV2319
SLBT8124
SLBM8426V

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S Swaminathan et al.
Nature structural biology, 7(8), 693-699 (2000-08-10)
Clostridium botulinum neurotoxins are among the most potent toxins to humans. The crystal structures of intact C. botulinum neurotoxin type B (BoNT/B) and its complex with sialyllactose, determined at 1. 8 and 2.6 A resolution, respectively, provide insight into its
J C Wilson et al.
Bioorganic & medicinal chemistry letters, 10(24), 2791-2794 (2001-01-02)
1H NMR spectroscopy has been used to investigate the transfer of sialic acid from sialic acid donor molecules to acceptor molecules using the trans-sialidase from Typanosoma cruzi. It is clearly demonstrated that NMR spectroscopy is an efficient and powerful means
C F Verkoelen et al.
Kidney international, 57(3), 1072-1082 (2000-03-18)
We studied the role of cell surface sialic acid in the adherence of calcium oxalate monohydrate (COM) crystals to Madin-Darby canine kidney (MDCK) cells. Studies were performed with undifferentiated (crystal-binding) cells in subconfluent cultures and maturated (noncrystal-binding) cells in confluent
S Crennell et al.
Nature structural biology, 7(11), 1068-1074 (2000-11-04)
Paramyxoviruses are the main cause of respiratory disease in children. One of two viral surface glycoproteins, the hemagglutinin-neuraminidase (HN), has several functions in addition to being the major surface antigen that induces neutralizing antibodies. Here we present the crystal structures
Tadasu Urashima et al.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 146(2), 153-159 (2006-11-23)
Samples of milk from a Bryde's whale and a Sei whale contained 2.7 g/100 mL and 1.7 g/100 mL of hexose, respectively. Both contained lactose as the dominant saccharide along with small amounts of Neu5Ac(alpha2-3)Gal(beta1-4)Glc (3'-N-acetylneuraminyllactose), Neu5Ac(alpha2-6)Gal(beta1-4)Glc (6'-N-acetylneuraminyllactose) and Neu5Ac(alpha2-6)Gal(beta1-4)GlcNAc(beta1-3)Gal(beta1-4)Glc
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Review of O-Linked Glycoproteins

O-Linked glycoproteins are usually large proteins with a molecular mass of >200 kDa. Glycosylation generally occurs in high-density clusters and may represent as much as 50-80% of the overall mass.

O-连接糖蛋白回顾

O-连接糖蛋白通常是分子量>200kDa的大蛋白。糖基化通常发生在高密度簇上，并可占总量的50-80%。

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