A8699
Activin Receptor IIA human
>95% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder
biological source
human
recombinant
expressed in baculovirus infected Sf21 cells
assay
>95% (SDS-PAGE)
form
lyophilized powder
mol wt
calculated mol wt 40 kDa
storage condition
avoid repeated freeze/thaw cycles
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... ACVR2A(92)
Biochem/physiol Actions
Activin isoforms are members of the TGF-β superfamily that bind to heteromeric complexes of a type I and a type II serine/threonine kinase receptor, both of which are essential for signal transduction. In addition to the activin isoforms, activin receptor II binds inhibin, BMP-2 and BMP-7. Human, murine and rat type II activin receptors demonstrate greater than 98% homology.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5 mg bovine serum albumin.
Analysis Note
The biological activity is measured by its ability to inhibit hemoglobin expression induced by activin in K562 cells.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
L Attisano et al.
Molecular and cellular biology, 16(3), 1066-1073 (1996-03-01)
Activin exerts its effects by simultaneously binding to two types of p rotein serine/threonine kinase receptors, each type existing in various isoforms. Using the ActR-IB and ActR-IIB receptor isoforms, we have investigated the mechanism of activin receptor activation. ActR-IIB are
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