A8754
Methyl α-aminoisobutyrate hydrochloride
别名:
α-Aminoisobutyric acid methyl ester hydrochloride
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关于此项目
经验公式（希尔记法）:
C5H11NO2 · HCl
化学文摘社编号:
分子量:
153.61
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
InChI
1S/C5H11NO2.ClH/c1-5(2,6)4(7)8-3;/h6H2,1-3H3;1H
SMILES string
Cl.COC(=O)C(C)(C)N
InChI key
NVWZNEDLYYLQJC-UHFFFAOYSA-N
assay
≥98% (TLC)
form
powder
technique(s)
ligand binding assay: suitable
color
white
storage temp.
−20°C
Biochem/physiol Actions
Methyl α-aminoisobutyrate is used as a specific substrate of amino acid transport system A in studies on amino acid transport systems.
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Oak Z Chi et al.
Neurochemical research, 34(7), 1249-1254 (2009-01-08)
This study was performed to determine whether exogenous N-methyl-D: -aspartate (NMDA) or alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) would aggravate blood-brain barrier (BBB) disruption in focal cerebral ischemia in rats. Forty-five minutes after middle cerebral artery (MCA) occlusion, one of the following
A Gadea et al.
Glia, 26(4), 273-279 (1999-06-26)
Rapid termination of the synaptic action of glutamate (Glu) and glycine (Gly) is achieved by uptake into the presynaptic terminal and glial cells. In the vertebrate CNS, Gly acts both as an inhibitory neurotransmitter and as a Glu modulator or
J W Tsang et al.
Journal of medicinal chemistry, 27(12), 1663-1668 (1984-12-01)
Stereochemical and structural aspects of the variations in the C-terminal residue of L-aspartyl-L-phenylalanine methyl ester have been investigated. Novel configurational analogues such as L-aspartyl-D-alanine benzyl ester and L-aspartyl-D-alpha-aminobutyric acid benzyl ester were found to be sweet. In addition, chiral and
Koichi Kato et al.
Bioorganic & medicinal chemistry letters, 21(8), 2437-2440 (2011-03-12)
We describe the synthesis of (11)C-labeled α-aminoisobutyric acid 2 from iodo[(11)C]methane and methyl N-(diphenylmethylen)-d,l-alaniate (5). The tetrabutylammonium fluoride (TBAF)-promoted α-[(11)C]methylation of sterically hindered analog 5 was a key step in our synthesis process. Total radiochemical conversion of 2 was high
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